Publication: Antimicrobial susceptibility of Streptococcus pneumoniae isolated from patients with respiratory tract infections in Thailand
Issued Date
2008-05-01
Resource Type
ISSN
01251562
Other identifier(s)
2-s2.0-44949226986
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Mahidol University
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SCOPUS
Bibliographic Citation
Southeast Asian Journal of Tropical Medicine and Public Health. Vol.39, No.3 (2008), 461-466
Suggested Citation
Somporn Srifuengfung, Chanwit Tribuddharat, Preecha Champreeda, Justin Daniels, Kulkanya Chokephaibulkit, Nithita Wongwan, Pitimon Polwichai Antimicrobial susceptibility of Streptococcus pneumoniae isolated from patients with respiratory tract infections in Thailand. Southeast Asian Journal of Tropical Medicine and Public Health. Vol.39, No.3 (2008), 461-466. Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/19691
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Title
Antimicrobial susceptibility of Streptococcus pneumoniae isolated from patients with respiratory tract infections in Thailand
Abstract
A total of 400 clinical Streptococcus pneumoniae strains from patients with respiratory diseases were collected from January 2002 to December 2005. In this study, an increased prevalence of penicillin-nonsusceptible S. pneumoniae (PNSP) from 63% in 2002-2003 to 69% in 2004-2005 was found. During 2004-2005, 56% were erythromycin-nonsusceptible S. pneumoniae (ENSP) and 54% were both PNSP and ENSP. The PNSP, ENSP and PNSP+ENSP groups showed similar trends, ie, sensitive to amoxicillin/clavulanate (range 97.2-98.5%), levofloxacin (range 90.7-92.4%), ceftriaxone (range 87.1-89.4%), and ofloxacin (range 64.8-66.1%). Lower levels of susceptibility were detected for azithromycin, clarithromycin, cefdinir, cefprozil, clindamycin, co-trimoxazole, chloramphenicol and tetracycline in penicillin and erythromycin-nonsusceptible strains. Of the macrolide-resistant S. pneumoniae, 55% of strains exhibited the M phenotype and 45% the constitutive MLSBphenotype. No pneumococci with the inducible MLSBphenotype were detected in Thailand.