Publication: A randomized, double-blind, placebo-controlled trial of acetazolamide for the treatment of elevated intracranial pressure in cryptococcal meningitis
Issued Date
2002-09-15
Resource Type
ISSN
10584838
DOI
Other identifier(s)
2-s2.0-0037105698
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Clinical Infectious Diseases. Vol.35, No.6 (2002), 769-772
Suggested Citation
Paul N. Newton, Hung Thai Le, Quoc Tip Nguyen, Jennifer M. Short, Wirongrong Chierakul, Adul Rajanuwong, Punnee Pitisuttithum, Sanchai Chasombat, Benjaluck Phonrat, Wirach Maek-A-Nantawat, Reungsilp Teaunadi, David G. Lalloo, Nicholas J. White A randomized, double-blind, placebo-controlled trial of acetazolamide for the treatment of elevated intracranial pressure in cryptococcal meningitis. Clinical Infectious Diseases. Vol.35, No.6 (2002), 769-772. doi:10.1086/342299 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/20358
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Title
A randomized, double-blind, placebo-controlled trial of acetazolamide for the treatment of elevated intracranial pressure in cryptococcal meningitis
Abstract
We conducted a trial of oral acetazolamide for the treatment of cryptococcal meningitis in 22 Thai adults with headache and an opening cerebrospinal fluid pressure of ≥200 mm H2O. The trial was terminated prematurely because patients who received acetazolamide developed significantly lower venous bicarbonate levels and higher chloride levels and had more-frequent serious adverse events than did subjects who received placebo.