Publication: Toxicity evaluation of sappan wood extract in rats
13
Issued Date
2010-12-01
Resource Type
ISSN
01252208
Other identifier(s)
2-s2.0-79952529032
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Journal of the Medical Association of Thailand. Vol.93, No.SUPPL 7 (2010)
Suggested Citation
Seeewaboon Sireeratawon, Pritsana Piyabha, Tippaya Singhala, Yuvadee Wongkrajan, Rungravi Temsiririrkku, Jakkapun Punsrira, Nongluck Ruangwise, Sumarn Saray, Nusiri Lerdvuthisopo, Kanjana Jaijo Toxicity evaluation of sappan wood extract in rats. Journal of the Medical Association of Thailand. Vol.93, No.SUPPL 7 (2010). Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/29408
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
Toxicity evaluation of sappan wood extract in rats
Other Contributor(s)
Abstract
Background: The heartwood of Caesalpinia sappan L. or sappan wood has long been used in folk medicines to treat tuberculosis, diarrhea, dysentery, skin infections and anemia. Objective: To study the acute and subacute toxicities of sappan wood extract in rats. Material and Method: For studying acute toxicity, a single oral dose of 5,000 mg/kg of sappan wood was administered to rats. Subacute toxicity was studied by the daily oral administration of the extract at the doses of 250, 500 and 1,000 mg/kg body weight for consecutive 30 days. Results: The extract of sappan wood (5,000 mg/kg) showed no toxicity in terms of general behavior change, mortality, or change in gross appearance of internal organs. Subacute toxicity study showed no abnormalities in treatment groups as compared to the controls. Body and organ weights, hematological, blood chemical, necropsy, and histopathological parameter of all groups were similar. Conclusion: Sappan wood extract did not produce any acute or subacute toxicity in both female and male rats.