Publication: Bioactive flavonoids of the flowers of Butea monosperma
3
Issued Date
2009-04-30
Resource Type
ISSN
13475223
00092363
00092363
Other identifier(s)
2-s2.0-65349113642
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Chemical and Pharmaceutical Bulletin. Vol.57, No.4 (2009), 428-432
Suggested Citation
Ratchanaporn Chokchaisiri, Channarong Suaisom, Siriluk Sriphota, Anon Chindaduang, Thipphawan Chuprajob, Apichart Suksamrarn Bioactive flavonoids of the flowers of Butea monosperma. Chemical and Pharmaceutical Bulletin. Vol.57, No.4 (2009), 428-432. doi:10.1248/cpb.57.428 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/27424
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
Bioactive flavonoids of the flowers of Butea monosperma
Other Contributor(s)
Abstract
One new dihydrochalcone, dihydromonospermoside (7), was isolated from the flowers of Butea monosperma together with three known chalcones, butein (2), monospermoside (4) and isoliquiritigenin (8), one flavone, 7,3',4'- trihydroxyflavone (6), four flavanones, (-)-butin (1a), (-)-butrin (3a), (+)-isomonospermoside (5b) and (-)-liquiritigenin (9a), and three isoflavones, formononetin (10), afrormosin (11) and formononetin-7-O-β-D-glu- copyranoside (12). The structure of the new compound was elucidated by spectroscopic techniques whereas those of the known compounds were identified by comparisons of spectroscopic and some physical data with those of reported compounds. The absolute configurations at the 2-position of the flavanones 1a, 3a, 5b and 9a were established to be 2S, 2S, 2R and 2S, respectively, by circular dichroism spectral measurements and were confirmed by comparison of the optical rotations with those of reported values and by enzymic hydrolysis of the glucosides to the corresponding aglycones. The isolated flavonoids exhibited varying antimycobacterial activity with the chalcone 2 being the most active compound (MIC 12.5 μg/ml). © 2009 Pharmaceutical Society of Japan.