Publication: AcGI1, a novel genomic island carrying antibiotic resistance integron In687 in multidrug resistant Achromobacter xylosoxidans in a teaching hospital in Thailand
| dc.contributor.author | Pisut Pongchaikul | en_US |
| dc.contributor.author | Pitak Santanirand | en_US |
| dc.contributor.author | Svetlana Antonyuk | en_US |
| dc.contributor.author | Craig Winstanley | en_US |
| dc.contributor.author | Alistair C. Darby | en_US |
| dc.contributor.other | University of Liverpool | en_US |
| dc.contributor.other | Faculty of Medicine, Ramathibodi Hospital, Mahidol University | en_US |
| dc.contributor.other | Mahidol University | en_US |
| dc.date.accessioned | 2020-08-25T09:03:35Z | |
| dc.date.available | 2020-08-25T09:03:35Z | |
| dc.date.issued | 2020-07-01 | en_US |
| dc.description.abstract | © FEMS 2020. This study investigated the genetic basis of multidrug resistance in two strains of Achromobacter xylosoxidans isolated from patients attending a hospital in Thailand in 2012. These isolates were highly resistant to cephalosporins, aminoglycosides, fluoroquinolones, co-trimoxazole and carbapenems. Whole genome sequencing revealed that the two isolates were not clonally related and identified a carbapenem resistance gene-habouring integron (In687), residing in a novel genomic island, AcGI1. This In687 shares 100% identical nucleotide sequence with ones found in Acinetobacter baumannii Aci 16, isolated from the same hospital in 2007. We report the first analysis of multidrug-resistant A. xylosoxidans isolated in Thailand, and the first example of this island in A. xylosoxidans. Our data support the idea that resistance has spread in Thailand via horizontal gene transfer between species and suggest the possibility of A. xylosoxidans may serve as a reservoir of antibiotic resistance, especially in hospital setting. | en_US |
| dc.identifier.citation | FEMS microbiology letters. Vol.367, No.14 (2020) | en_US |
| dc.identifier.doi | 10.1093/femsle/fnaa109 | en_US |
| dc.identifier.issn | 15746968 | en_US |
| dc.identifier.other | 2-s2.0-85088492018 | en_US |
| dc.identifier.uri | https://repository.li.mahidol.ac.th/handle/20.500.14594/57707 | |
| dc.rights | Mahidol University | en_US |
| dc.rights.holder | SCOPUS | en_US |
| dc.source.uri | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85088492018&origin=inward | en_US |
| dc.subject | Biochemistry, Genetics and Molecular Biology | en_US |
| dc.subject | Immunology and Microbiology | en_US |
| dc.title | AcGI1, a novel genomic island carrying antibiotic resistance integron In687 in multidrug resistant Achromobacter xylosoxidans in a teaching hospital in Thailand | en_US |
| dc.type | Article | en_US |
| dspace.entity.type | Publication | |
| mu.datasource.scopus | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85088492018&origin=inward | en_US |