Publication: Estimating the effectiveness of isolation and decolonization measures in reducing transmission of methicillin-resistant Staphylococcus aureus in hospital general wards.
Accepted Date
2012-09-07
Issued Date
2013-06-01
Copyright Date
2013
Resource Type
Language
eng
ISSN
0002-9262 (printed)
1476-6256 (electronic)
1476-6256 (electronic)
Rights
Mahidol University
Rights Holder(s)
PubMed Central
Bibliographic Citation
Worby CJ, Jeyaratnam D, Robotham JV, Kypraios T, O'Neill PD, De Angelis D. et al. Estimating the effectiveness of isolation and decolonization measures in reducing transmission of methicillin-resistant Staphylococcus aureus in hospital general wards. Am J Epidemiol. 2013 Jun 1;177(11):1306-13.
Suggested Citation
Worby, Colin J., Jeyaratnam, Dakshika, Robotham, Julie V., Kypraios, Theodore, O’Neill, Philip D., Angelis, Daniela De, French, Gary, Cooper, Ben S. Estimating the effectiveness of isolation and decolonization measures in reducing transmission of methicillin-resistant Staphylococcus aureus in hospital general wards.. Worby CJ, Jeyaratnam D, Robotham JV, Kypraios T, O'Neill PD, De Angelis D. et al. Estimating the effectiveness of isolation and decolonization measures in reducing transmission of methicillin-resistant Staphylococcus aureus in hospital general wards. Am J Epidemiol. 2013 Jun 1;177(11):1306-13.. doi:10.1093/aje/kws380. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/836
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Title
Estimating the effectiveness of isolation and decolonization measures in reducing transmission of methicillin-resistant Staphylococcus aureus in hospital general wards.
Corresponding Author(s)
Abstract
Infection control for hospital pathogens such as methicillin-resistant
Staphylococcus aureus (MRSA) often takes the form of a package of interventions,
including the use of patient isolation and decolonization treatment. Such
interventions, though widely used, have generated controversy because of their
significant resource implications and the lack of robust evidence with regard to
their effectiveness at reducing transmission. The aim of this study was to
estimate the effectiveness of isolation and decolonization measures in reducing
MRSA transmission in hospital general wards. Prospectively collected MRSA
surveillance data from 10 general wards at Guy's and St. Thomas' hospitals,
London, United Kingdom, in 2006-2007 were used, comprising 14,035 patient
episodes. Data were analyzed with a Markov chain Monte Carlo algorithm to model
transmission dynamics. The combined effect of isolation and decolonization was
estimated to reduce transmission by 64% (95% confidence interval: 37, 79).
Undetected MRSA-positive patients were estimated to be the source of 75% (95%
confidence interval: 67, 86) of total transmission events. Isolation measures
combined with decolonization treatment were strongly associated with a reduction
in MRSA transmission in hospital general wards. These findings provide support
for active methods of MRSA control, but further research is needed to determine
the relative importance of isolation and decolonization in preventing
transmission.