Publication:
A non-comparative trial of the efficacy and safety of fexofenadine for treatment of perennial allergic rhinitis

dc.contributor.authorC. Bunnagen_US
dc.contributor.authorP. Jareoncharsrien_US
dc.contributor.authorP. Tunsuriyawongen_US
dc.contributor.authorP. Pumhirunen_US
dc.contributor.authorS. Limprasertsirien_US
dc.contributor.authorL. Chochaipanichnonen_US
dc.contributor.authorP. Supiyaphunen_US
dc.contributor.authorS. Kongpatanakulen_US
dc.contributor.otherMahidol Universityen_US
dc.date.accessioned2018-09-07T09:11:13Z
dc.date.available2018-09-07T09:11:13Z
dc.date.issued2000-12-01en_US
dc.description.abstractAn open-label, non-comparative study was performed in three Otolaryngology centers in Bangkok, Thailand, to assess the efficacy, safety and tolerability of fexofenadine in Thai patients with perennial allergic rhinitis. Altogether 101 perennial allergic rhinitis patients were included, 33 males and 68 females. Mean age was 33 years, average duration of symptoms was 6 years. All patients received fexofenadine hydrochloride 120 mg once daily (OD) in the morning for 2 weeks. Patients recorded their allergy symptoms daily using a 5 point rating scales in the diary card. At the end of 2 weeks, patients and investigators assessed the overall efficacy of treatment. Adverse events and onset of symptom relief were also recorded by every patient. Blood test and ECG were performed before and after treatment in one center (Siriraj Hospital). Total symptom scores and nasal scores decreased significantly from a baseline at 1 week and 2 weeks after treatment (p < 0.05). The mean onset of symptom relief was 2 hours and 12 minutes. The global assessment of the treatment by patients and investigators showed significant concordance. There was no significant change in either the vital signs, laboratory tests or ECG. The incidence of treatment related adverse events was 8% but all were mild and easily tolerated. Drowsiness was reported from only one patient. This study suggests that fexofenadine 120 mg once daily was an effective, safe and well tolerated treatment for perennial allergic rhinitis in Thai patients.en_US
dc.identifier.citationAsian Pacific Journal of Allergy and Immunology. Vol.18, No.3 (2000), 127-133en_US
dc.identifier.issn0125877Xen_US
dc.identifier.other2-s2.0-0034525394en_US
dc.identifier.urihttps://repository.li.mahidol.ac.th/handle/20.500.14594/25957
dc.rightsMahidol Universityen_US
dc.rights.holderSCOPUSen_US
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0034525394&origin=inwarden_US
dc.subjectImmunology and Microbiologyen_US
dc.subjectMedicineen_US
dc.titleA non-comparative trial of the efficacy and safety of fexofenadine for treatment of perennial allergic rhinitisen_US
dc.typeArticleen_US
dspace.entity.typePublication
mu.datasource.scopushttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0034525394&origin=inwarden_US

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