Publication: Treatment of a brain abscess caused by scedosporium apiospermum and phaeoacremonium parasiticum in a renal transplant recipient
Issued Date
2013-05-01
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ISSN
01251562
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2-s2.0-84882647727
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Mahidol University
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SCOPUS
Bibliographic Citation
Southeast Asian Journal of Tropical Medicine and Public Health. Vol.44, No.3 (2013), 484-489
Suggested Citation
Noppadol Larbcharoensub, Piriyaporn Chongtrakool, Chewarat Wirojtananugoon, Siriorn P. Watcharananan, Vasant Sumethkul, Atthaporn Boongird, Sopon Jirasiritham Treatment of a brain abscess caused by scedosporium apiospermum and phaeoacremonium parasiticum in a renal transplant recipient. Southeast Asian Journal of Tropical Medicine and Public Health. Vol.44, No.3 (2013), 484-489. Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/32362
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Title
Treatment of a brain abscess caused by scedosporium apiospermum and phaeoacremonium parasiticum in a renal transplant recipient
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Abstract
Cerebral mycosis is a significant cause of morbidity among immunocompromised populations. We present here a case of cerebral infection with Scedosporium apiospermum and Phaeoacremonium parasiticum in a 49-year-old renal transplant recipient. Fourteen years after renal transplantation, the patient presented with invasive pulmonary aspergillosis treated with intravenous liposomal amphotericin B. The patient had clinical and radiographic improvement. However, 6 weeks later, the patient presented with cerebral infection. Magnetic resonance imaging revealed multiple rim enhancing brain abscesses. Brain and cerebrospinal fluid cultures ultimately grew Scedosporium apiospermum and Phaeoacremonium parasiticum. The patient was treated with voriconazole for 6 months and had clinical and radiologic improvement. We believe this is the first reported case of co-infection of the brain with scedosporiosis and phaeohyphomycosis in a renal transplant recipient, who had received intravenous liposomal amphotericin B. Voriconazole may represent a new therapeutic option for these simultaneous infections in the brain.