Publication:
Decoding the RNA viromes in rodent lungs provides new insight into the origin and evolutionary patterns of rodent-borne pathogens in Mainland Southeast Asia

Issued Date

2021-12-01

Resource Type

Article

ISSN

20492618

DOI

10.1186/s40168-020-00965-z

Other identifier(s)

2-s2.0-85099857650

Rights

Mahidol University

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SCOPUS

Bibliographic Citation

Microbiome. Vol.9, No.1 (2021)

Suggested Citation

Zhiqiang Wu, Yelin Han, Bo Liu, Hongying Li, Guangjian Zhu, Alice Latinne, Jie Dong, Lilin Sun, Haoxiang Su, Liguo Liu, Jiang Du, Siyu Zhou, Mingxing Chen, Anamika Kritiyakan, Sathaporn Jittapalapong, Kittipong Chaisiri, Phillipe Buchy, Veasna Duong, Jian Yang, Jinyong Jiang, Xiang Xu, Hongning Zhou, Fan Yang, David M. Irwin, Serge Morand, Peter Daszak, Jianwei Wang, Qi Jin Decoding the RNA viromes in rodent lungs provides new insight into the origin and evolutionary patterns of rodent-borne pathogens in Mainland Southeast Asia. Microbiome. Vol.9, No.1 (2021). doi:10.1186/s40168-020-00965-z Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/77189

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Title

Decoding the RNA viromes in rodent lungs provides new insight into the origin and evolutionary patterns of rodent-borne pathogens in Mainland Southeast Asia

Author(s)

Zhiqiang Wu
 Yelin Han
 Bo Liu
 Hongying Li
 Guangjian Zhu
 Alice Latinne
 Jie Dong
 Lilin Sun
 Haoxiang Su
 Liguo Liu
 Jiang Du
 Siyu Zhou
 Mingxing Chen
 Anamika Kritiyakan
 Sathaporn Jittapalapong
 Kittipong Chaisiri
 Phillipe Buchy
 Veasna Duong
 Jian Yang
 Jinyong Jiang
 Xiang Xu
 Hongning Zhou
 Fan Yang
 David M. Irwin
 Serge Morand
 Peter Daszak
 Jianwei Wang
 Qi Jin

Other Contributor(s)

Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College
 Chinese Academy of Medical Sciences & Peking Union Medical College
 GlaxoSmithKline, Singapore
 EcoHealth Alliance
 Institut Pasteur du Cambodge
 Kasetsart University
 University of Toronto
 Mahidol University
 Wildlife Conservation Society
 Wildlife Conservation Society
 Yunnan Institute of Parasitic Diseases

Abstract

Background: As the largest group of mammalian species, which are also widely distributed all over the world, rodents are the natural reservoirs for many diverse zoonotic viruses. A comprehensive understanding of the core virome of diverse rodents should therefore assist in efforts to reduce the risk of future emergence or re-emergence of rodent-borne zoonotic pathogens. Results: This study aimed to describe the viral range that could be detected in the lungs of rodents from Mainland Southeast Asia. Lung samples were collected from 3284 rodents and insectivores of the orders Rodentia, Scandentia, and Eulipotyphla in eighteen provinces of Thailand, Lao PDR, and Cambodia throughout 2006–2018. Meta-transcriptomic analysis was used to outline the unique spectral characteristics of the mammalian viruses within these lungs and the ecological and genetic imprints of the novel viruses. Many mammalian- or arthropod-related viruses from distinct evolutionary lineages were reported for the first time in these species, and viruses related to known pathogens were characterized for their genomic and evolutionary characteristics, host species, and locations. Conclusions: These results expand our understanding of the core viromes of rodents and insectivores from Mainland Southeast Asia and suggest that a high diversity of viruses remains to be found in rodent species of this area. These findings, combined with our previous virome data from China, increase our knowledge of the viral community in wildlife and arthropod vectors in emerging disease hotspots of East and Southeast Asia. [MediaObject not available: see fulltext.]

Keyword(s)

Immunology and Microbiology
 Medicine

Availability

URI

https://repository.li.mahidol.ac.th/handle/20.500.14594/77189

Collections

Scopus 2021