Publication: A genetically immortalized human stem cell line: A promising new tool for Alzheimer’s disease therapy
Issued Date
2015-10-21
Resource Type
ISSN
16112156
Other identifier(s)
2-s2.0-84946061251
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
EXCLI Journal. Vol.14, (2015), 1135-1144
Suggested Citation
Nicha Puangmalai, Alyma Somani, Wipawan Thangnipon, Clive Ballard, Martin Broadstock A genetically immortalized human stem cell line: A promising new tool for Alzheimer’s disease therapy. EXCLI Journal. Vol.14, (2015), 1135-1144. doi:10.17179/excli2015-560 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/35085
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
A genetically immortalized human stem cell line: A promising new tool for Alzheimer’s disease therapy
Other Contributor(s)
Abstract
© 2015, Leibniz Research Centre for Working Environment and Human Factors. All rights reserved. Amyloid-β peptides and hyper-phosphorylated tau are the main pathological hallmarks of Alzheimer’s disease (AD). Given the recent failure of several large-scale clinical trials and the lack of disease-modifying pharmacological treatments, there is an urgent need to develop alternative therapies. A clinical grade human CTX0E03 neural stem cell line has recently passed phase I trials in people with stroke. However, this cell line has not been investigated in other neurodegenerative disorders. This study investigates the survival of CTX0E03 cells under conditions based on the underlying AD pathology. Cell viability assays showed a concentration dependence of this cell line to the toxic effects of Aβ1-42, but not Aβ1-40, and okadaic acid, a phosphatase 2A inhibitor. Notably, CTX0E03 cell line displayed toxicity at concentrations significantly higher than both rat neural stem cells and those previously reported for primary cultures. These results suggest CTX0E03 cells could be developed for clinical trials in AD patients.