Publication: Fengycin-A Novel Antifungal Lipopeptide Antibiotic Produced by Bacillus Subtilis F-29-3
Issued Date
1986-01-01
Resource Type
ISSN
18811469
00218820
00218820
Other identifier(s)
2-s2.0-0022457256
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Journal of Antibiotics. Vol.39, No.7 (1986), 888-901
Suggested Citation
Nongnuch Vanittanakom, Wolfgang Loeffler, Ulrike Koch, GüNther Jung Fengycin-A Novel Antifungal Lipopeptide Antibiotic Produced by Bacillus Subtilis F-29-3. Journal of Antibiotics. Vol.39, No.7 (1986), 888-901. doi:10.7164/antibiotics.39.888 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/9874
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
Fengycin-A Novel Antifungal Lipopeptide Antibiotic Produced by Bacillus Subtilis F-29-3
Other Contributor(s)
Abstract
Fengycin is an antifungal lipopeptide complex produced by Bacillus subtilis strain F-29-3. It inhibits filamentous fungi but is ineffective against yeast and bacteria. The inhibition is antagonized by sterols, phospholipids and oleic acid, whereas two other unsaturated fatty acids increase the antifungal effect. Fengycin consists of two main components differing by one amino acid exchange. Fengycin A is composed of 1 D-Ala, 1 L-Ile, 1 L-Pro, 1 D-allo-Thr, 3 L-G1X, 1 D-Tyr, 1 L-Tyr, 1 D-Orn, whereas in fengycin B the D-Ala is replaced by D-Val. The lipid moiety of both analogs is more variable, as fatty acids have been identified as anteiso-pentadecanoic acid (ai-C 15 ), iso-hexadecanoic acid (i-C 16 ), n-hexadecanoic acid (n-C 16 ), and there is evidence for further saturated and unsaturated residues up to C 18 . © 1986, JAPAN ANTIBIOTICS RESEARCH ASSOCIATION. All rights reserved.