Publication: Molecular docking studies and anti-tyrosinase activity of thai mango seed kernel extract
Issued Date
2009-01-01
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ISSN
14203049
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2-s2.0-59149085366
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Mahidol University
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SCOPUS
Bibliographic Citation
Molecules. Vol.14, No.1 (2009), 257-265
Suggested Citation
Saruth Nithitanakool, Pimolpan Pithayanukul, Rapepol Bavovada, Patchreenart Saparpakorn Molecular docking studies and anti-tyrosinase activity of thai mango seed kernel extract. Molecules. Vol.14, No.1 (2009), 257-265. doi:10.3390/molecules14010257 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/27446
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Title
Molecular docking studies and anti-tyrosinase activity of thai mango seed kernel extract
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Abstract
The alcoholic extract from seed kernels of Thai mango (Mangifera indica L. cv. 'Fahlun') (Anacardiaceae) and its major phenolic principle (pentagalloylglucopyranose) exhibited potent, dose-dependent inhibitory effects on tyrosinase with respect to L-DOPA. Molecular docking studies revealed that the binding orientations of the phenolic principles were in the tyrosinase binding pocket and their orientations were located in the hydrophobic binding pocket surrounding the binuclear copper active site. The results indicated a possible mechanism for their anti-tyrosinase activity which may involve an ability to chelate the copper atoms which are required for the catalytic activity of tyrosinase. © 2009 by the authors; licensee Molecular Diversity Preservation International.