Publication: Analysis of circumsporozoite protein-specific immune responses following recent infection with Plasmodium vivax
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2004-07-01
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00029637
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2-s2.0-3142615801
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Mahidol University
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SCOPUS
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American Journal of Tropical Medicine and Hygiene. Vol.71, No.1 (2004), 29-39
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Chaisuree Suphavilai, Sornchai Looareesuwan, Michael F. Good Analysis of circumsporozoite protein-specific immune responses following recent infection with Plasmodium vivax. American Journal of Tropical Medicine and Hygiene. Vol.71, No.1 (2004), 29-39. Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/21372
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Analysis of circumsporozoite protein-specific immune responses following recent infection with Plasmodium vivax
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CD8+ and CD4+ T cells are involved in immunity to the pre-erythrocytic stage of malaria. This study has been undertaken to define T cell epitopes on the Plasmodium vivax circumsporozoite protein (CSP) and to analyze the early induction of immune response following infection. We identified CD4+ and CD8+ T epitopes recognized by different strains of mice as well as by humans. The CD4+ T cell response in mice was found to be similar in all strains, but variation between strains was evident. Five H-2d-restricted CD8+ cytotoxic T lymphocyte (CTL) epitopes, but no H-2k-or H-2b-restricted epitopes, could be defined. Non-H-2 genes were also able to regulate the response. In recently infected Thai adults, poor immunoresponsiveness was demonstrated. CTL activity and proliferative responses of T cells from malaria-exposed donors were very low. In contrast, exposed individuals had specific antibodies against the immunodominant repeats of both common strains of the P. vivax CSP; however, titers decreased following treatment.