Publication: Spectrum of cutaneous adverse reactions to aromatic antiepileptic drugs and human leukocyte antigen genotypes in Thai patients and meta-analysis
Issued Date
2021-12-01
Resource Type
ISSN
14731150
1470269X
1470269X
Other identifier(s)
2-s2.0-85108814525
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Pharmacogenomics Journal. Vol.21, No.6 (2021), 682-690
Suggested Citation
Chonlaphat Sukasem, Suthida Sririttha, Chonlawat Chaichan, Thapanat Nakkrut, Patompong Satapornpong, Kanoot Jaruthamsophon, Thawinee Jantararoungtong, Napatrupron Koomdee, Sadeep Medhasi, Sarawut Oo-Puthinan, Ticha Rerkpattanapipat, Jettanong Klaewsongkram, Pawinee Rerknimitr, Papapit Tuchinda, Leena Chularojanamontri, Napatra Tovanabutra, Naravut Suvannang, Thanyada Rungrotmongkol, Surasak Saokaew, Wichai Aekplakorn, Apichaya Puangpetch Spectrum of cutaneous adverse reactions to aromatic antiepileptic drugs and human leukocyte antigen genotypes in Thai patients and meta-analysis. Pharmacogenomics Journal. Vol.21, No.6 (2021), 682-690. doi:10.1038/s41397-021-00247-3 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/75931
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
Spectrum of cutaneous adverse reactions to aromatic antiepileptic drugs and human leukocyte antigen genotypes in Thai patients and meta-analysis
Author(s)
Chonlaphat Sukasem
Suthida Sririttha
Chonlawat Chaichan
Thapanat Nakkrut
Patompong Satapornpong
Kanoot Jaruthamsophon
Thawinee Jantararoungtong
Napatrupron Koomdee
Sadeep Medhasi
Sarawut Oo-Puthinan
Ticha Rerkpattanapipat
Jettanong Klaewsongkram
Pawinee Rerknimitr
Papapit Tuchinda
Leena Chularojanamontri
Napatra Tovanabutra
Naravut Suvannang
Thanyada Rungrotmongkol
Surasak Saokaew
Wichai Aekplakorn
Apichaya Puangpetch
Suthida Sririttha
Chonlawat Chaichan
Thapanat Nakkrut
Patompong Satapornpong
Kanoot Jaruthamsophon
Thawinee Jantararoungtong
Napatrupron Koomdee
Sadeep Medhasi
Sarawut Oo-Puthinan
Ticha Rerkpattanapipat
Jettanong Klaewsongkram
Pawinee Rerknimitr
Papapit Tuchinda
Leena Chularojanamontri
Napatra Tovanabutra
Naravut Suvannang
Thanyada Rungrotmongkol
Surasak Saokaew
Wichai Aekplakorn
Apichaya Puangpetch
Other Contributor(s)
Ramathibodi Hospital
Siriraj Hospital
Faculty of Tropical Medicine, Mahidol University
University of Phayao
Chulalongkorn University
Faculty of Medicine, Prince of Songkia University
Rangsit University
Naresuan University
Bumrungrad International Hospital
Faculty of Medicine Ramathibodi Hospital, Mahidol University
Mahidol University
Faculty of Medicine, Chulalongkorn University
Chiang Mai University
Triamwitpattana school
The Thai Severe Cutaneous Adverse Drug Reaction (THAI-SCAR) Research Group
Neurological Institute of Thailand
Siriraj Hospital
Faculty of Tropical Medicine, Mahidol University
University of Phayao
Chulalongkorn University
Faculty of Medicine, Prince of Songkia University
Rangsit University
Naresuan University
Bumrungrad International Hospital
Faculty of Medicine Ramathibodi Hospital, Mahidol University
Mahidol University
Faculty of Medicine, Chulalongkorn University
Chiang Mai University
Triamwitpattana school
The Thai Severe Cutaneous Adverse Drug Reaction (THAI-SCAR) Research Group
Neurological Institute of Thailand
Abstract
Aromatic antiepileptic drugs (AEDs)-induced cutaneous adverse drug reactions (cADRs) add up to the limited use of the AEDs in the treatment and prevention of seizures. Human leukocyte antigen-B (HLA-B) alleles have been linked to AEDs-induced cADRs. We investigated the association between cADRs (including Stevens–Johnson syndrome; SJS/toxic epidermal necrolysis; TEN, drug reaction with eosinophilia and systemic symptoms; DRESS, and Maculopapular eruption; MPE) caused by AEDs (phenytoin, carbamazepine, lamotrigine, phenobarbital and oxcarbazepine) and HLA-B alleles in Thai population. Through the case-control study, 166 patients with AEDs-induced cADRs, 426 AEDs-tolerant patients (AEDs-tolerant controls), and 470 healthy subjects (Thai population) were collected. The HLA genotypes were detected using the polymerase chain reaction-sequence specific oligonucleotide probe (PCR-SSOP) method. We also performed a meta-analysis with these data and other populations. The carrier rate of HLA-B*15:02 was significantly different between AEDs-induced cADRs group and AEDs-tolerant group (Odds ratio; OR 4.28, 95% Confidence interval; CI 2.64–6.95, p < 0.001), AEDs-induced cADRs group and Thai population (OR 2.15, 95%CI 1.41–3.29, p < 0.001). In meta-analysis showed the strong association HLA-B*15:02 with AEDs-induced cADRs (OR 4.77, 95%CI 1.79–12.73, p < 0.001). Furthermore, HLA-B*15:02 was associated with SJS/TEN induced by AEDs (OR 10.28, 95%CI 6.50–16.28, p < 0.001) Phenytoin (OR 4.12, 95%CI 1.77–9.59, p = 0.001) and carbamazepine (OR 137.69, 95%CI 50.97–371.98, p < 0.001). This study demonstrated that genetic association for AEDs-induced cADRs was phenotype-specific. A strong association between HLA-B*15:02 and AEDs-induced SJS/TEN was demonstrated with an OR of 10.79 (95%CI 5.50–21.16, p < 0.001) when compared with AEDs-tolerant group. On the other hand, the carrier rates of HLA-B*08:01, HLA-B*13:01, and HLA-B*56:02 were significantly higher in the DRESS group compared with the AEDs-tolerant group (p = 0.029, 0.007, and 0.017, respectively). The HLA-B*15:02 allele may represent a risk factor for AEDs-induced cADRs.