Publication: Environmental lead exposure, catalase gene, and markers of antioxidant and oxidative stress relation to hypertension: An analysis based on the EGAT study
2
Issued Date
2015-02-22
Resource Type
ISSN
23146141
23146133
23146133
Other identifier(s)
2-s2.0-84924529836
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
BioMed Research International. Vol.2015, (2015)
Suggested Citation
Jintana Sirivarasai, Sukhumpun Kaojarern, Suwannee Chanprasertyothin, Pachara Panpunuan, Krittaya Petchpoung, Aninthita Tatsaneeyapant, Krongtong Yoovathaworn, Thunyachai Sura, Sming Kaojarern, Piyamit Sritara Environmental lead exposure, catalase gene, and markers of antioxidant and oxidative stress relation to hypertension: An analysis based on the EGAT study. BioMed Research International. Vol.2015, (2015). doi:10.1155/2015/856319 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/35497
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
Environmental lead exposure, catalase gene, and markers of antioxidant and oxidative stress relation to hypertension: An analysis based on the EGAT study
Other Contributor(s)
Abstract
© 2015 Jintana Sirivarasai et al. Lead has been linked to the development of hypertension via oxidative stress. Catalase plays an important role in the disposal of hydrogen peroxide in erythrocyte and its activity was determined by CAT gene. The aims of this study were to investigate (1) the association between blood levels of antioxidant markers such as catalase, superoxide dismutase, glutathione, glutathione peroxidase, oxidative stress-marker (malondialdehyde), and blood lead level and (2) the influence of genetic polymorphism of CAT gene (rs769217) on change in blood pressure in general population of EGAT study project. This is a cross-sectional study of 332 normotensive, 432 prehypertensive, and 222 hypertensive male subjects. Hypertensive subjects had significantly higher blood lead level (5.28 g/dL) compared to normotensive (4.41 g/dL) and prehypertensive (4.55 g/dL) subjects (P < 0.05). These significant findings are also found in MDA levels. Moreover, individuals with TT genotype in hypertensive group had significantly higher blood lead and MDA levels (6.06 g/dL and 9.67 mol/L) than those with CC genotype (5.32 g/dL and 8.31 mol/L, P < 0.05). Our findings suggested that decreased blood catalase activity in this polymorphism together with low level lead exposure induced lipid peroxidation may be responsible for hypertension.