Vitamin K prophylaxis in the neonate by the oral route and its significance in reducing infant mortality and morbidity

dc.contributor.authorP. B. Isarangkuraen_US
dc.contributor.authorP. Bintadishen_US
dc.contributor.authorA. Tejavejen_US
dc.contributor.authorP. Siripoonyaen_US
dc.contributor.authorR. Chulajataen_US
dc.contributor.authorG. M. Greenen_US
dc.contributor.authorK. Chalermchandraen_US
dc.contributor.otherMahidol Universityen_US
dc.description.abstractVitamin K in oral drops and intramuscular injection given at birth to Thai infants were compared to determine whether these routes and doses would influence prothrombin complex activity, mortality or morbidity at 0.5, 1 and 2 months of age. The infants were 321 normal fullterm babies born at Bangkok Adventist Hospital in 1983, exclusively breastfed during the study. Prothrombin complex (PC) was measured by the Owren capillary thrombotest method using a reagent from Nyegaard Co., Oslo. Vitamin K was given in single 1 or 2 mg oral doses, or 1 mg im, within 12 hours of delivery. Judging by the number of PC deficient children, the 1 mg im and 2 mg oral doses of vitamin K maintained clotting factors best at 2 months of age. All formulations were significantly better than no treatment at 1 month at age. No toxicity or side effects were seen. Vitamin K deficiency is a known cause of bleeding disorders, particularly fatal and handicapping intracranial hemorrhage in newborns, in developing countries where injections cannot be given by midwives. These inexpensive oral pediatric drops may provide a practical form of primary health care for routine vitamin K prophylaxis in newborns.en_US
dc.identifier.citationJournal of the Medical Association of Thailand. Vol.69, No.SUPPL. 2 (1986), 56-61en_US
dc.rightsMahidol Universityen_US
dc.titleVitamin K prophylaxis in the neonate by the oral route and its significance in reducing infant mortality and morbidityen_US