Publication: Expression of isoferritins in peripheral blood lymphocytes: Effect of phytohaemagglutinin and iron
Issued Date
1989-01-01
Resource Type
ISSN
16000609
09024441
09024441
Other identifier(s)
2-s2.0-0024455078
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
European Journal of Haematology. Vol.43, No.2 (1989), 143-149
Suggested Citation
Kovit Pattanapanyasat Expression of isoferritins in peripheral blood lymphocytes: Effect of phytohaemagglutinin and iron. European Journal of Haematology. Vol.43, No.2 (1989), 143-149. doi:10.1111/j.1600-0609.1989.tb00270.x Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/15827
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
Expression of isoferritins in peripheral blood lymphocytes: Effect of phytohaemagglutinin and iron
Author(s)
Other Contributor(s)
Abstract
This study shows that incubation of lymphocytes in phytohaemagglutinin medium together with iron supplementation leads to an increase of ferritin synthesis concomitant with increased intracellular ferritin concentration especially of heart‐type ferritin. Increasing levels of iron do not increase heart‐type ferritin concentration further; in contrast, spleen‐type ferritin is gradually increased with increasing iron levels. The preferential increase in spleen‐type ferritin on growth in iron‐enriched medium may be explained by two distinct roles in the metabolism of these two isoferritins. Heart‐type isoferritin appears to be involved in more active iron metabolism in lymphocytes whilst the spleen‐type isoferritin may function as an intracellular depot of excess iron that is not immediately utilised for metabolic activity. © Munksgaard 1989