Publication: 16<sup>th</sup>IHIW: Anti-HLA alloantibodies of the of IgA isotype in re-transplant candidates
Issued Date
2013-02-01
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ISSN
1744313X
17443121
17443121
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2-s2.0-84872264921
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Mahidol University
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SCOPUS
Bibliographic Citation
International Journal of Immunogenetics. Vol.40, No.1 (2013), 17-20
Suggested Citation
M. L. Arnold, F. M. Heinemann, P. Horn, M. Ziemann, N. Lachmann, A. Mühlbacher, A. Dick, A. Ender, D. Thammanichanond, G. F. Fischer, S. Schaub, M. Hallensleben, J. Mytilineos, W. E. Hitzler, C. Seidl, I. I.N. Doxiadis, B. M. Spriewald 16<sup>th</sup>IHIW: Anti-HLA alloantibodies of the of IgA isotype in re-transplant candidates. International Journal of Immunogenetics. Vol.40, No.1 (2013), 17-20. doi:10.1111/iji.12032 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/31374
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Title
16<sup>th</sup>IHIW: Anti-HLA alloantibodies of the of IgA isotype in re-transplant candidates
Other Contributor(s)
Friedrich-Alexander-Universität Erlangen-Nürnberg
Universitats Klinikum Essen und Medizinische Fakultat
Universitatsklinikum Schleswig-Holstein Campus Lubeck
Charité – Universitätsmedizin Berlin
University Hospital Innsbruck
Klinikum der Universitat Munchen
Klinikum Stuttgart Katharinenhospital
Mahidol University
Medizinische Universitat Wien
Universitatsspital Basel
Medizinische Hochschule Hannover (MHH)
Universitatsklinikum Ulm
Klinikum der Johannes-Gutenberg-Universitat und Fachbereich Medizin
Institute for Transfusion Medicine and Immunohaematology
Leiden University Medical Center - LUMC
Universitats Klinikum Essen und Medizinische Fakultat
Universitatsklinikum Schleswig-Holstein Campus Lubeck
Charité – Universitätsmedizin Berlin
University Hospital Innsbruck
Klinikum der Universitat Munchen
Klinikum Stuttgart Katharinenhospital
Mahidol University
Medizinische Universitat Wien
Universitatsspital Basel
Medizinische Hochschule Hannover (MHH)
Universitatsklinikum Ulm
Klinikum der Johannes-Gutenberg-Universitat und Fachbereich Medizin
Institute for Transfusion Medicine and Immunohaematology
Leiden University Medical Center - LUMC
Abstract
In this multicentre study, sera from 803 retransplant candidates, including 775 kidney transplant recipients, were analysed with regard to the presence and specificity of anti-HLA alloantibodies of the IgA isotype using a modified microsphere-based platform. Of the kidney recipients, nearly one-third (n = 237, 31%) had IgA alloantibodies. Mostly, these antibodies were found in sera that also harboured IgG alloantibodies that could be found in a total of 572 (74%) of patients. Interestingly, IgA anti-HLA antibodies were preferentially targeting HLA class I antigens in contrast to those of the IgG isotype, which targeted mostly both HLA class I and II antigens. Donor specificity of the IgA alloantibodies could be established for over half of the 237 patients with IgA alloantibodies (n = 124, 52%). A further 58 patients had specificities against HLA-C or HLA-DP, for which no information regarding donor typing was available. In summary, these data showed in a large cohort of retransplant candidates that IgA alloantibodies occur in about one-third of patients, about half of these antibodies being donor specific. © 2012 Blackwell Publishing Ltd.