Publication:
Mapping human genetic diversity in Asia

Issued Date

2009-12-11

Resource Type

Article

ISSN

10959203
00368075

DOI

10.1126/science.1177074

Other identifier(s)

2-s2.0-72149083621

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

Science. Vol.326, No.5959 (2009), 1541-1545

Suggested Citation

Mahmood Ameen Abdulla, Ikhlak Ahmed, Anunchai Assawamakin, Jong Bhak, Samir K. Brahmachari, Gayvelline C. Calacal, Amit Chaurasia, Chien Hsiun Chen, Jieming Chen, Yuan Tsong Chen, Jiayou Chu, Eva Maria C. Cutiongco-de La Paz, Maria Corazon A. De Ungria, Frederick C. Delfin, Juli Edo, Suthat Fuchareon, Ho Ghang, Takashi Gojobori, Junsong Han, Sheng Feng Ho, Boon Peng Hoh, Wei Huang, Hidetoshi Inoko, Pankaj Jha, Timothy A. Jinam, Li Jin, Jongsun Jung, Daoroong Kangwanpong, Jatupol Kampuansai, Giulia C. Kennedy, Preeti Khurana, Hyung Lae Kim, Kwangjoong Kim, Sangsoo Kim, Woo Yeon Kim, Kuchan Kimm, Ryosuke Kimura, Tomohiro Koike, Supasak Kulawonganunchai, Vikrant Kumar, Poh San Lai, Jong Young Lee, Sunghoon Lee, Edison T. Liu, Partha P. Majumder, Kiran Kumar Mandapati, Sangkot Marzuki, Wayne Mitchell, Mitali Mukerji, Kenji Naritomi, Chumpol Ngamphiw, Norio Niikawa, Nao Nishida, Bermseok Oh, Sangho Oh, Jun Ohashi, Akira Oka, Rick Ong, Carmencita D. Padilla, Prasit Palittapongarnpim, Henry B. Perdigon, Maude Elvira Phipps, Eileen Png, Yoshiyuki Sakaki, Jazelyn M. Salvador, Yuliana Sandraling, Vinod Scaria, Mark Seielstad, Mohd Ros Sidek, Amit Sinha, Metawee Srikummool, Herawati Sudoyo, Sumio Sugano, Helena Suryadi, Yoshiyuki Suzuki, Kristina A. Tabbada, Adrian Tan, Katsushi Tokunaga, Sissades Tongsima, Lilian P. Villamor, Eric Wang, Ying Wang, Haifeng Wang, Jer Yuarn Wu, Huasheng Xiao, Shuhua Xu, Jin Ok Yang, Yin Yao Shugart, Hyang Sook Yoo, Wentao Yuan, Guoping Zhao, Bin Alwi Zilfalil Mapping human genetic diversity in Asia. Science. Vol.326, No.5959 (2009), 1541-1545. doi:10.1126/science.1177074 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/28380

Research Projects

Organizational Units

Authors

Journal Issue

Thesis

Title

Mapping human genetic diversity in Asia

Author(s)

Mahmood Ameen Abdulla
 Ikhlak Ahmed
 Anunchai Assawamakin
 Jong Bhak
 Samir K. Brahmachari
 Gayvelline C. Calacal
 Amit Chaurasia
 Chien Hsiun Chen
 Jieming Chen
 Yuan Tsong Chen
 Jiayou Chu
 Eva Maria C. Cutiongco-de La Paz
 Maria Corazon A. De Ungria
 Frederick C. Delfin
 Juli Edo
 Suthat Fuchareon
 Ho Ghang
 Takashi Gojobori
 Junsong Han
 Sheng Feng Ho
 Boon Peng Hoh
 Wei Huang
 Hidetoshi Inoko
 Pankaj Jha
 Timothy A. Jinam
 Li Jin
 Jongsun Jung
 Daoroong Kangwanpong
 Jatupol Kampuansai
 Giulia C. Kennedy
 Preeti Khurana
 Hyung Lae Kim
 Kwangjoong Kim
 Sangsoo Kim
 Woo Yeon Kim
 Kuchan Kimm
 Ryosuke Kimura
 Tomohiro Koike
 Supasak Kulawonganunchai
 Vikrant Kumar
 Poh San Lai
 Jong Young Lee
 Sunghoon Lee
 Edison T. Liu
 Partha P. Majumder
 Kiran Kumar Mandapati
 Sangkot Marzuki
 Wayne Mitchell
 Mitali Mukerji
 Kenji Naritomi
 Chumpol Ngamphiw
 Norio Niikawa
 Nao Nishida
 Bermseok Oh
 Sangho Oh
 Jun Ohashi
 Akira Oka
 Rick Ong
 Carmencita D. Padilla
 Prasit Palittapongarnpim
 Henry B. Perdigon
 Maude Elvira Phipps
 Eileen Png
 Yoshiyuki Sakaki
 Jazelyn M. Salvador
 Yuliana Sandraling
 Vinod Scaria
 Mark Seielstad
 Mohd Ros Sidek
 Amit Sinha
 Metawee Srikummool
 Herawati Sudoyo
 Sumio Sugano
 Helena Suryadi
 Yoshiyuki Suzuki
 Kristina A. Tabbada
 Adrian Tan
 Katsushi Tokunaga
 Sissades Tongsima
 Lilian P. Villamor
 Eric Wang
 Ying Wang
 Haifeng Wang
 Jer Yuarn Wu
 Huasheng Xiao
 Shuhua Xu
 Jin Ok Yang
 Yin Yao Shugart
 Hyang Sook Yoo
 Wentao Yuan
 Guoping Zhao
 Bin Alwi Zilfalil

Other Contributor(s)

University of Malaya
 Institute of Genomics and Integrative Biology India
 Mahidol University
 Thailand National Center for Genetic Engineering and Biotechnology
 Korea Research Institute of Bioscience and Biotechnology
 University of the Philippines Diliman
 Institute of Biomedical Sciences Academia Sinica Taiwan
 Genome Institute of Singapore
 Chinese Academy of Medical Sciences
 University of the Philippines Manila
 Research Organization of Information and Systems
 National Institute of Advanced Industrial Science and Technology
 National Engineering Center for Biochip at Shanghai
 School of Medical Sciences - Universiti Sains Malaysia
 Chinese National Human Genome Center at Shanghai
 Tokai University School of Medicine
 Fudan University
 Korea National Institute of Health
 Chiang Mai University
 Thermo Fisher Scientific
 Veracyte, Inc.
 Soongsil University
 Eulji University
 University of Tokyo
 Yong Loo Lin School of Medicine
 DSO National Laboratories
 Indian Statistical Institute, Kolkata
 Eijkman Institute for Molecular Biology
 Experimental Therapeutics Centre
 Nanyang Technological University School of Computer Engineering
 University of the Ryukyus Faculty of Medicine
 Thailand National Science and Technology Development Agency
 Monash University Malaysia
 RIKEN Genomic Sciences Center
 Shanghai Institute for Biological Sciences Chinese Academy of Sciences
 National Institute of Mental Health
 Health Sciences University of Hokkaido

Abstract

Asia harbors substantial cultural and linguistic diversity, but the geographic structure of genetic variation across the continent remains enigmatic. Here we report a large-scale survey of autosomal variation from a broad geographic sample of Asian human populations. Our results show that genetic ancestry is strongly correlated with linguistic affiliations as well as geography. Most populations show relatedness within ethnic/linguistic groups, despite prevalent gene flow among populations. More than 90% of East Asian (EA) haplotypes could be found in either Southeast Asian (SEA) or Central-South Asian (CSA) populations and show clinal structure with haplotype diversity decreasing from south to north. Furthermore, 50% of EA haplotypes were found in SEA only and 5% were found in CSA only, indicating that SEA was a major geographic source of EA populations.

Keyword(s)

Multidisciplinary

Availability

URI

https://repository.li.mahidol.ac.th/handle/20.500.14594/28380

Collections

Scopus 2006-2010