Publication:
Development and validation of serological markers for detecting recent Plasmodium vivax infection

Issued Date

2020-05-01

Resource Type

Article

ISSN

1546170X
10788956

DOI

10.1038/s41591-020-0841-4

Other identifier(s)

2-s2.0-85084626398

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

Nature Medicine. Vol.26, No.5 (2020), 741-749

Suggested Citation

Rhea J. Longley, Michael T. White, Eizo Takashima, Jessica Brewster, Masayuki Morita, Matthias Harbers, Thomas Obadia, Leanne J. Robinson, Fumie Matsuura, Zoe S.J. Liu, Connie S.N. Li-Wai-Suen, Wai Hong Tham, Julie Healer, Christele Huon, Chetan E. Chitnis, Wang Nguitragool, Wuelton Monteiro, Carla Proietti, Denise L. Doolan, Andre M. Siqueira, Xavier C. Ding, Iveth J. Gonzalez, James Kazura, Marcus Lacerda, Jetsumon Sattabongkot, Takafumi Tsuboi, Ivo Mueller Development and validation of serological markers for detecting recent Plasmodium vivax infection. Nature Medicine. Vol.26, No.5 (2020), 741-749. doi:10.1038/s41591-020-0841-4 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/56123

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Title

Development and validation of serological markers for detecting recent Plasmodium vivax infection

Author(s)

Rhea J. Longley
 Michael T. White
 Eizo Takashima
 Jessica Brewster
 Masayuki Morita
 Matthias Harbers
 Thomas Obadia
 Leanne J. Robinson
 Fumie Matsuura
 Zoe S.J. Liu
 Connie S.N. Li-Wai-Suen
 Wai Hong Tham
 Julie Healer
 Christele Huon
 Chetan E. Chitnis
 Wang Nguitragool
 Wuelton Monteiro
 Carla Proietti
 Denise L. Doolan
 Andre M. Siqueira
 Xavier C. Ding
 Iveth J. Gonzalez
 James Kazura
 Marcus Lacerda
 Jetsumon Sattabongkot
 Takafumi Tsuboi
 Ivo Mueller

Other Contributor(s)

Foundation for Innovative New Diagnostics, Switzerland
 Walter and Eliza Hall Institute of Medical Research
 University of Melbourne
 QIMR Berghofer Medical Research Institute
 James Cook University, Australia
 Riken
 Mahidol University
 CNRS Centre National de la Recherche Scientifique
 CASE School of Medicine
 Burnet Institute
 Universidade do Estado do Amazonas
 Ehime University
 Institut Pasteur, Paris
 Leônidas & Maria Deane Institute - Fiocruz Amazônia
 Fundação de Medicina Tropical Dr. Heitor Vieira Dourado
 Instituto Nacional de Infectologia Evandro Chagas
 CellFree Sciences Co., Ltd.

Abstract

© 2020, The Author(s), under exclusive licence to Springer Nature America, Inc. A major gap in the Plasmodium vivax elimination toolkit is the identification of individuals carrying clinically silent and undetectable liver-stage parasites, called hypnozoites. This study developed a panel of serological exposure markers capable of classifying individuals with recent P. vivax infections who have a high likelihood of harboring hypnozoites. We measured IgG antibody responses to 342 P. vivax proteins in longitudinal clinical cohorts conducted in Thailand and Brazil and identified candidate serological markers of exposure. Candidate markers were validated using samples from year-long observational cohorts conducted in Thailand, Brazil and the Solomon Islands and antibody responses to eight P. vivax proteins classified P. vivax infections in the previous 9 months with 80% sensitivity and specificity. Mathematical models demonstrate that a serological testing and treatment strategy could reduce P. vivax prevalence by 59–69%. These eight antibody responses can serve as a biomarker, identifying individuals who should be targeted with anti-hypnozoite therapy.

Keyword(s)

Biochemistry, Genetics and Molecular Biology

Availability

URI

https://repository.li.mahidol.ac.th/handle/20.500.14594/56123

Collections

Scopus 2020