Publication: Studies of the CETP TaqIB and ApoE Polymorphisms in Southern Thai Subjects with the Metabolic Syndrome
Issued Date
2015-08-29
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ISSN
15734927
00062928
00062928
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2-s2.0-84938292564
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Mahidol University
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SCOPUS
Bibliographic Citation
Biochemical Genetics. Vol.53, No.7-8 (2015), 184-199
Suggested Citation
Nutjaree Jeenduang, Sureerut Porntadavity, Manit Nuinoon, Dararat Horpet, Nongyao Thepkwan, Pattamawadee Thaworn, Suporn Theanmontri Studies of the CETP TaqIB and ApoE Polymorphisms in Southern Thai Subjects with the Metabolic Syndrome. Biochemical Genetics. Vol.53, No.7-8 (2015), 184-199. doi:10.1007/s10528-015-9680-2 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/35108
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Title
Studies of the CETP TaqIB and ApoE Polymorphisms in Southern Thai Subjects with the Metabolic Syndrome
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Abstract
© 2015, Springer Science+Business Media New York. Several genetic factors have been investigated responsible for metabolic syndrome (MetS). The aim of this study was to investigate the association between cholesteryl ester transfer protein (CETP) TaqIB and apolipoprotein E (ApoE) polymorphisms and MetS in 378 subjects from Southern Thailand. Subjects were divided into MetS+ (n = 121) and MetS− (n = 257) groups according to the criteria of National Cholesterol Education Program Adult Treatment Panel III (NCEP ATPIII). The CETP TaqIB and ApoE polymorphisms were analyzed by polymerase chain reaction–restriction fragment length polymorphism (PCR–RFLP) technique. Logistic regression analysis revealed no association of CETPTaqIB and ApoE variants with MetS, after adjustment for age and sex. However, ε4 allele had a significantly increased odds ratio (OR) of reduced high-density lipoprotein–cholesterol (HDL-C) levels when compared with ε3 allele (OR 1.91; 95 % CI 1.11–3.29, p = 0.020). This suggests that CETP TaqIB and ApoE polymorphisms may not be considered as genetic risk factors for MetS in a Southern Thai population. However, ε4 allele which is associated with one metabolic component, low HDL-C levels, might predispose the subjects to develop metabolic disturbances.