Publication: Effect of single-dose albendazole and single-dose mebendazole on Necator americanus.
Issued Date
1989-06-01
Resource Type
ISSN
01251562
Other identifier(s)
2-s2.0-0024675733
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Mahidol University
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SCOPUS
Bibliographic Citation
The Southeast Asian journal of tropical medicine and public health. Vol.20, No.2 (1989), 237-242
Suggested Citation
P. Nontasut, V. Singhasivanon, V. Prarinyanuparp, B. Chiamratana, S. Sanguankiat, P. Dekumyoy, P. Setasuban Effect of single-dose albendazole and single-dose mebendazole on Necator americanus.. The Southeast Asian journal of tropical medicine and public health. Vol.20, No.2 (1989), 237-242. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/15808
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Title
Effect of single-dose albendazole and single-dose mebendazole on Necator americanus.
Other Contributor(s)
Abstract
One hundred two children (43 males and 59 females) aged 6 to 14 years with positive stool examination by Kato-Katz and/or Harada-Mori culture techniques for N. americanus, were randomly divided into two groups. Group I with 48 children were treated with a single dose albendazole, 400 mg. Group II, 54 children, received a single dose mebendazole, 600 mg. After treatment, repeated stool examination was performed on Day 14, Day 21 and Day 28. The children were considered cured when stool examination was negative on all three occasions by both methods. The cure rate was 64% in Group I and 11% in Group II. The difference was statistically significant (p less than 0.05). The eggs reduction rate was 98% in Group I and 95% in Group II. Mild and transient side effects such as nausea, dizziness and headache were observed in both groups. Albendazole, 400 mg, as a single dose treatment was shown to be superior to mebendazole, 600 mg, single dose for the mass treatment of hookworm infection, especially that of Necator americanus, in an endemic area.