Publication:
HIV-1 envelope glycoproteins from diverse clades differentiate antibody responses and durability among vaccinees

Issued Date

2018-04-01

Resource Type

Article

ISSN

10985514
0022538X

DOI

10.1128/JVI.01843-17

Other identifier(s)

2-s2.0-85044631722

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

Journal of Virology. Vol.92, No.8 (2018)

Suggested Citation

Nicole L. Yates, Allan C. deCamp, Bette T. Korber, Hua Xin Liao, Carmela Irene, Abraham Pinter, James Peacock, Linda J. Harris, Sheetal Sawant, Peter Hraber, Xiaoying Shen, Supachai Rerks-Ngarm, Punnee Pitisuttithum, Sorachai Nitayapan, Phillip W. Berman, Merlin L. Robb, Giuseppe Pantaleo, Susan Zolla-Pazner, Barton F. Haynes, S. Munir Alam, David C. Montefiori, Georgia D. Tomaras HIV-1 envelope glycoproteins from diverse clades differentiate antibody responses and durability among vaccinees. Journal of Virology. Vol.92, No.8 (2018). doi:10.1128/JVI.01843-17 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/44791

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Title

HIV-1 envelope glycoproteins from diverse clades differentiate antibody responses and durability among vaccinees

Author(s)

Nicole L. Yates
 Allan C. deCamp
 Bette T. Korber
 Hua Xin Liao
 Carmela Irene
 Abraham Pinter
 James Peacock
 Linda J. Harris
 Sheetal Sawant
 Peter Hraber
 Xiaoying Shen
 Supachai Rerks-Ngarm
 Punnee Pitisuttithum
 Sorachai Nitayapan
 Phillip W. Berman
 Merlin L. Robb
 Giuseppe Pantaleo
 Susan Zolla-Pazner
 Barton F. Haynes
 S. Munir Alam
 David C. Montefiori
 Georgia D. Tomaras

Other Contributor(s)

University of California, Santa Cruz
 Centre Hospitalier Universitaire Vaudois
 Jinan University
 Armed Forces Research Institute of Medical Sciences, Thailand
 Thailand Ministry of Public Health
 HJF
 Icahn School of Medicine at Mount Sinai
 Walter Reed Army Institute of Research
 Mahidol University
 Los Alamos National Laboratory
 Rutgers New Jersey Medical School
 Duke University School of Medicine
 Fred Hutchinson Cancer Research Center

Abstract

© 2018 American Society for Microbiology. Induction of broadly cross-reactive antiviral humoral responses with the capacity to target globally diverse circulating strains is a key goal for HIV-1 immunogen design. A major gap in the field is the identification of diverse HIV-1 envelope antigens to evaluate vaccine regimens for binding antibody breadth. In this study, we define unique antigen panels to map HIV-1 vaccine-elicited antibody breadth and durability. Diverse HIV-1 envelope glycoproteins were selected based on genetic and geographic diversity to cover the global epidemic, with a focus on sexually acquired transmitted/founder viruses with a tier 2 neutralization phenotype. Unique antigenicity was determined by nonredundancy (Spearman correlation), and antigens were clustered using partitioning around medoids (PAM) to identify antigen diversity. Cross-validation demonstrated that the PAM method was better than selection by reactivity and random selection. Analysis of vaccine-elicited V1V2 binding antibody in longitudinal samples from the RV144 clinical trial revealed the striking heterogeneity among individual vaccinees in maintaining durable responses. These data support the idea that a major goal for vaccine development is to improve antibody levels, breadth, and durability at the population level. Elucidating the level and durability of vaccine-elicited binding antibody breadth needed for protection is critical for the development of a globally efficacious HIV vaccine.

Keyword(s)

Agricultural and Biological Sciences
 Immunology and Microbiology

Availability

URI

https://repository.li.mahidol.ac.th/handle/20.500.14594/44791

Collections

Scopus 2018