Publication: Endothelial cells in dengue hemorrhagic fever
Issued Date
2014-01-01
Resource Type
ISSN
18729096
01663542
01663542
Other identifier(s)
2-s2.0-84905189360
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Mahidol University
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SCOPUS
Bibliographic Citation
Antiviral Research. Vol.109, No.1 (2014), 160-170
Suggested Citation
Anon Srikiatkhachorn, James F. Kelley Endothelial cells in dengue hemorrhagic fever. Antiviral Research. Vol.109, No.1 (2014), 160-170. doi:10.1016/j.antiviral.2014.07.005 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/34056
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Title
Endothelial cells in dengue hemorrhagic fever
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Abstract
Therapies to prevent or reverse endothelial dysfunction and vascular leak found in dengue hemorrhagic fever (DHF) have not been identified. In this review we summarize dengue viruses and the spectrum of human disease and highlight evidence of endothelial cell dysfunction in DHF based on studies in patients and mouse and tissue culture models. Evidence suggests that both virus antigen and host immune response, can cause endothelial cell dysfunction and weaken endothelial barrier integrity. We suggest possible therapeutic interventions and highlight how therapies targeting altered endothelial function might be evaluated in animal models and in patients with DHF. © 2014 Elsevier B.V. All rights reserved.
