Publication: Malaria vaccine trials in a wormy world
Issued Date
2001-12-01
Resource Type
ISSN
14714922
Other identifier(s)
2-s2.0-0035698082
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Mahidol University
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SCOPUS
Bibliographic Citation
Trends in Parasitology. Vol.17, No.12 (2001), 563-565
Suggested Citation
Mathieu Nacher Malaria vaccine trials in a wormy world. Trends in Parasitology. Vol.17, No.12 (2001), 563-565. doi:10.1016/S1471-4922(01)02117-1 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/26548
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Title
Malaria vaccine trials in a wormy world
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Abstract
The promising malaria vaccine candidates that have been tested in the field have, so far, yielded disappointing and, at times, conflicting results. Considerable efforts are being made to isolate new immunogenic molecules. However, the fact that most populations in malaria endemic areas are also infected by helminths appears to be overlooked. Helminth-related hyporesponsiveness to tetanus or cholera vaccines, and the interactions between malaria parasites and helminths, raise the possibility that a potent malaria vaccine will not be identified in helminth-infected populations, thus necessitating a change in vaccine trial design.