Publication:
Changes in renal function with long-term exposure to antiretroviral therapy in HIV-infected adults in Asia

Issued Date

2018-11-01

Resource Type

Article

ISSN

10991557
10538569

DOI

10.1002/pds.4657

Other identifier(s)

2-s2.0-85053721521

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

Pharmacoepidemiology and Drug Safety. Vol.27, No.11 (2018), 1209-1216

Suggested Citation

Kedar Joshi, David Boettiger, Stephen Kerr, Takeshi Nishijima, Kinh Van Nguyen, Penh Sun Ly, Man Po Lee, Nagalingeswaran Kumarasamy, Wingwai Wong, Pacharee Kantipong, Do Duy Cuong, Adeeba Kamarulzaman, Jun Yong Choi, Fujie Zhang, Romanee Chaiwarith, Oon Tek Ng, Sasisopin Kiertiburanakul, Benedict Lim Heng Sim, Tuti Parwati Merati, Evy Yunihastuti, Rossana Ditangco, Jeremy Ross, Sanjay Pujari Changes in renal function with long-term exposure to antiretroviral therapy in HIV-infected adults in Asia. Pharmacoepidemiology and Drug Safety. Vol.27, No.11 (2018), 1209-1216. doi:10.1002/pds.4657 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/46234

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Title

Changes in renal function with long-term exposure to antiretroviral therapy in HIV-infected adults in Asia

Author(s)

Kedar Joshi
 David Boettiger
 Stephen Kerr
 Takeshi Nishijima
 Kinh Van Nguyen
 Penh Sun Ly
 Man Po Lee
 Nagalingeswaran Kumarasamy
 Wingwai Wong
 Pacharee Kantipong
 Do Duy Cuong
 Adeeba Kamarulzaman
 Jun Yong Choi
 Fujie Zhang
 Romanee Chaiwarith
 Oon Tek Ng
 Sasisopin Kiertiburanakul
 Benedict Lim Heng Sim
 Tuti Parwati Merati
 Evy Yunihastuti
 Rossana Ditangco
 Jeremy Ross
 Sanjay Pujari

Other Contributor(s)

Hospital Sungai Buloh
 Beijing Ditan Hospital
 VHS Medical Centre India
 Gokila
 Bach Mai Hospital
 Universitas Udayana
 University of Indonesia, RSUPN Dr. Cipto Mangunkusumo
 Kirby Institute
 National Center for Global Health and Medicine
 The HIV Netherlands Australia Thailand Research Collaboration
 Yonsei University College of Medicine
 Faculty of Medicine, Ramathibodi Hospital, Mahidol University
 Queen Elizabeth Hospital Hong Kong
 University of Malaya Medical Centre
 Veterans General Hospital-Taipei
 Tan Tock Seng Hospital
 National Hospital for Tropical Diseases
 National Center for HIV/AIDS
 amfAR - The Foundation for AIDS Research
 Institute of Infectious Diseases
 Chiangrai Prachanukroh Hospital
 Research Institute for Health Sciences

Abstract

© 2018 John Wiley & Sons, Ltd. Purpose: Renal disease is common among people living with human immunodeficiency virus (HIV). However, there is limited information on the incidence and risk factors associated with renal dysfunction among this population in Asia. Methods: We used data from the TREAT Asia HIV Observational Database. Patients were included if they started antiretroviral therapy during or after 2003, had a serum creatinine measurement at antiretroviral therapy initiation (baseline), and had at least 2 follow-up creatinine measurements taken ≥3 months apart. Patients with a baseline estimated glomerular filtration rate (eGFR) ≤60 mL/min/1.73 m2 were excluded. Chronic kidney disease was defined as 2 consecutive eGFR values ≤60 mL/min/1.73 m2 taken ≥3 months apart. Generalized estimating equations were used to identify factors associated with eGFR change. Competing risk regression adjusted for study site, age and sex, and cumulative incidence plots were used to evaluate factors associated with chronic kidney disease (CKD). Results: Of 2547 patients eligible for this analysis, tenofovir was being used by 703 (27.6%) at baseline. Tenofovir use, high baseline eGFR, advanced HIV disease stage, and low nadir CD4 were associated with a decrease in eGFR during follow-up. Chronic kidney disease occurred at a rate of 3.4 per 1000 patient/years. Factors associated with CKD were tenofovir use, old age, low baseline eGFR, low nadir CD4, and protease inhibitor use. Conclusions: There is an urgent need to enhance renal monitoring and management capacity among at-risk groups in Asia and improve access to less nephrotoxic antiretrovirals.

Keyword(s)

Medicine

Availability

URI

https://repository.li.mahidol.ac.th/handle/20.500.14594/46234

Collections

Scopus 2018