Publication: Naproxen for pain relief during endometrial biopsy: A randomized controlled trial
Issued Date
2015-01-01
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ISSN
01252208
01252208
01252208
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2-s2.0-84938087461
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Mahidol University
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SCOPUS
Bibliographic Citation
Journal of the Medical Association of Thailand. Vol.98, No.7 (2015), 631-635
Suggested Citation
Werapath Somchit, Arb Aroon Lertkhachonsuk, Sakda Arj Ong Vallipakorn Naproxen for pain relief during endometrial biopsy: A randomized controlled trial. Journal of the Medical Association of Thailand. Vol.98, No.7 (2015), 631-635. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/36633
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Title
Naproxen for pain relief during endometrial biopsy: A randomized controlled trial
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Abstract
© 2015, Medical Association of Thailand. All rights reserved. Objective: To evaluate the effectiveness of naproxen 500 mg taken orally 30 minutes before endometrial biopsy for pain relief during the procedure. Material and Method: A double blind, randomized, placebo-controlled trial was conducted in 80 patients with indication for endometrial biopsy at Ramathibodi Hospital between April 2013 and January 2014. The patients were randomly allocated into two groups to receive naproxen 500 mg (n = 40) or placebo (n = 40), 30 minutes before endometrial biopsy. Pain score was assessed using Visual Analogue Scale during and 10 minutes after the procedure. Adverse events were observed. Results: The mean pain score during endometrial biopsy in the treatment group was significantly lower compared to the placebo group (5.11±0.18 vs. 6.49±0.17, respectively, p-value <0.001). However, the mean pain score at 10 minutes after endometrial sampling were minimal and had non-statistical significance in both groups. (0.60±0.56 vs. 0.59±0.64, p-value 0.971). Conclusion: Naproxen 500 mg taken orally 30 minutes before endometrial biopsy significantly reduce pain score during the procedure.