Publication: Impaired local immune response in vitamin A-deficient rats
Issued Date
1980-07-11
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ISSN
00099104
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2-s2.0-0018883934
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Mahidol University
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SCOPUS
Bibliographic Citation
Clinical and Experimental Immunology. Vol.40, No.1 (1980), 127-135
Suggested Citation
S. Sirisinha, M. D. Darip, P. Moongkarndi, M. Ongsakul, A. J. Lamb Impaired local immune response in vitamin A-deficient rats. Clinical and Experimental Immunology. Vol.40, No.1 (1980), 127-135. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/11105
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Title
Impaired local immune response in vitamin A-deficient rats
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Abstract
The functional integrity of the local immune system in vitamin A-deficient (A - ) rats was investigated. Secretory IgA levels in the intestinal fluid of A - rats were significantly lower than in controls. This and the decrease in intensity of immunofluorescent staining for secretory component (SC) in the intestinal cells was related to the duration of vitamin A deprivation. IgG levels in the intestinal fluid, and serum IgA and IgG levels were unaffected in deficiency. Moreover, when the response of animals to DNP 50 -BGG was evaluated, the local anti-DNP response in the intestine was markedly depressed. These defects may result from impaired synthesis of SC by epithelial cells. On the other hand, the serum antibody response in deficient animals was not noticeably different from that of the controls; if any, there was a slight reduction in the affinity of antibody.