Publication: Lower tumorigenesis without life extension in rats receiving lifelong deep ocean minerals
Issued Date
2020-01-01
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ISSN
20457634
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2-s2.0-85082965466
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Mahidol University
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SCOPUS
Bibliographic Citation
Cancer Medicine. (2020)
Suggested Citation
Suchada Saovieng, Jinfu Wu, Wei Horng Jean, Chih Yang Huang, Matthew F. Higgins, Ahmad Alkhatib, Mallikarjuna Korivi, Chiao Nan Chen, Chia Hua Kuo Lower tumorigenesis without life extension in rats receiving lifelong deep ocean minerals. Cancer Medicine. (2020). doi:10.1002/cam4.3028 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/54495
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Title
Lower tumorigenesis without life extension in rats receiving lifelong deep ocean minerals
Other Contributor(s)
Tzu Chi University of Science and Technology
University of Taipei
National Yang-Ming University Taiwan
Far Eastern Memorial Hospital Taiwan
China Medical University Hospital Taichung
Teesside University
Buddhist Tzu-Chi General Hospital Taiwan
Tzu Chi University
University of Derby
Mahidol University
China Medical University Taichung
South China Normal University
Zhejiang Normal University
University of Taipei
National Yang-Ming University Taiwan
Far Eastern Memorial Hospital Taiwan
China Medical University Hospital Taichung
Teesside University
Buddhist Tzu-Chi General Hospital Taiwan
Tzu Chi University
University of Derby
Mahidol University
China Medical University Taichung
South China Normal University
Zhejiang Normal University
Abstract
© 2020 The Authors. Cancer Medicine published by John Wiley & Sons Ltd. Naturally occurring tumor in animals receiving high minerals from deep oceans (DOM: hardness 600 mg/L) from 6 months of age until natural death was firstly assessed in 200 Sprague Dawley rats, randomized into four groups: Control (C), DOM (D), Fructose (F), and Fructose + DOM (FD). Fructose drink contained 11% fructose. Tumor incidence (necropsy at death) in the D group was ~40% lower than that in the C group (P <.05), together with lower body mass gain and greater locomotive activity during their initial 18 months (P <.05) but not during later life. X-ray image analysis on abnormal solid tissue among survivors at 18 and 24 months of age confirms a similar trend, exhibiting ~50% and ~65% lower tumor incidence than the C and F groups, respectively. Reduced-to-oxidized glutathione ratio (GSH/GSSG) declined with age for the first three quarters of life on all groups (P <.05), followed by a resurgence during end-life among survivors at 24 months. This resurgence is markedly associated with lower tumor expansion but unrelated with DOM supplementation. Our results demonstrate valuable application of minerals and trace elements from deep oceans, as a vastly available natural source, on tumor suppression during normal aging.