Publication: Coumarins and flavones from the fruit and root extracts of Micromelum integerrimum
Issued Date
2018-01-01
ISSN
14786427
14786419
14786419
Other identifier(s)
2-s2.0-85056201149
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Natural Product Research. (2018)
Suggested Citation
Virayu Suthiphasilp, Wisanu Maneerat, Raymond J. Andersen, Stephen G. Pyne, Chatchai Muanprasat, Sawinee Seemakhan, Suparerk Borwornpinyo, Surat Laphookhieo Coumarins and flavones from the fruit and root extracts of Micromelum integerrimum. Natural Product Research. (2018). doi:10.1080/14786419.2018.1510400 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/44899
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
Coumarins and flavones from the fruit and root extracts of Micromelum integerrimum
Abstract
© 2018, © 2018 Informa UK Limited, trading as Taylor & Francis Group. A phytochemical investigation of the fruit and root extracts of Micromelum integerrimum resulted in the isolation and identification of a new compound, integerravone (1), together with 23 known compounds (2–24). Their structures were characterized by spectroscopic methods as well as comparisons made from the literature. Compounds 2, 3–15, 17–18 and 20–23 were evaluated for their cytotoxicities against the colon cancer cell line, HCT116. All of them were inactive at 50 µM. Most of the phenolic compounds were evaluated for their antioxidant activity using the DPPH assay. Compounds 14 and 22–24 showed antioxidant activity with IC50 values ranging from 24.83-135.05 µM.