Publication: Leptospira interrogans is recognized through DC-SIGN and induces maturation and cytokine production by human dendritic cells
Issued Date
2008-08-01
Resource Type
ISSN
1574695X
09288244
09288244
Other identifier(s)
2-s2.0-48449105049
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Mahidol University
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SCOPUS
Bibliographic Citation
FEMS Immunology and Medical Microbiology. Vol.53, No.3 (2008), 359-367
Suggested Citation
Narintorn Gaudart, Pattama Ekpo, Kovit Pattanapanyasat, Yvette Van Kooyk, Anneke Engering Leptospira interrogans is recognized through DC-SIGN and induces maturation and cytokine production by human dendritic cells. FEMS Immunology and Medical Microbiology. Vol.53, No.3 (2008), 359-367. doi:10.1111/j.1574-695X.2008.00437.x Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/19306
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Title
Leptospira interrogans is recognized through DC-SIGN and induces maturation and cytokine production by human dendritic cells
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Abstract
Leptospirosis is a global zoonotic disease, caused by pathogenic Leptospira species including Leptospira interrogans, that causes public health and livestock problems. Pathogenesis, immune response and cellular receptors for Leptospira are not well understood. Interaction of dendritic cells (DCs) with L. interrogans serovar Autumnalis L-643 and BL-6 isolated from leptospirosis patients, and both virulent and avirulent serovar Pyrogenes 2317 strains isolated from animal were investigated. Carbohydrate analysis using lectins showed that all of these leptospires contained high mannose components as a common backbone and DC-SIGN was involved in leptospires' attachment. Interaction of the L. interrogans strains with DCs induced maturation, but had different effects on IL-10, IL-12p70 and tumor necrosis factor (TNF)-α production. Both virulent and avirulent Pyrogenes 2317 and Autumnalis BL-6 but not L-643 strains induced IL-12p70 and TNF-α production, but minimal IL-10 secretion. These data demonstrated that L. interrogans binds DC-SIGN and induces DCs maturation and cytokine production, which should provide new insights into cellular immune processes during leptospirosis. © 2008 Federation of European Microbiological Societies. Published by Blackwell Publishing Ltd. All rights reserved.