Publication: Antimalarial drug resistance
Issued Date
2004-01-01
Resource Type
ISSN
00219738
DOI
Other identifier(s)
2-s2.0-2142659388
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Journal of Clinical Investigation. Vol.113, No.8 (2004), 1084-1092
Suggested Citation
Nicholas J. White Antimalarial drug resistance. Journal of Clinical Investigation. Vol.113, No.8 (2004), 1084-1092. doi:10.1172/JCI21682 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/21747
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Title
Antimalarial drug resistance
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Abstract
Malaria, the most prevalent and most pernicious parasitic disease of humans, is estimated to kill between one and two million people, mainly children, each year. Resistance has emerged to all classes of antimalarial drugs except the artemisinins and is responsible for a recent increase in malaria-related mortality, particularly in Africa. The de novo emergence of resistance can be prevented by the use of antimalarial drug combinations. Artemisinin-derivative combinations are particularly effective, since they act rapidly and are well tolerated and highly effective. Widespread use of these drugs could roll back malaria.