Publication: Preoperative Psychosocial and Psychophysical Phenotypes as Predictors of Acute Pain Outcomes After Breast Surgery
Issued Date
2019-05-01
Resource Type
ISSN
15288447
15265900
15265900
Other identifier(s)
2-s2.0-85059786202
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Mahidol University
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SCOPUS
Bibliographic Citation
Journal of Pain. Vol.20, No.5 (2019), 540-556
Suggested Citation
Kristin L. Schreiber, Nantthasorn Zinboonyahgoon, Xinling Xu, Tara Spivey, Tari King, Laura Dominici, Ann Partridge, Mehra Golshan, Gary Strichartz, Rob R. Edwards Preoperative Psychosocial and Psychophysical Phenotypes as Predictors of Acute Pain Outcomes After Breast Surgery. Journal of Pain. Vol.20, No.5 (2019), 540-556. doi:10.1016/j.jpain.2018.11.004 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/51695
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Title
Preoperative Psychosocial and Psychophysical Phenotypes as Predictors of Acute Pain Outcomes After Breast Surgery
Abstract
© 2018 the American Pain Society The severity and impact of acute pain after breast surgery varies markedly among individuals, underlining the importance of comprehensively identifying specific risk factors, including psychosocial and psychophysical traits. In this prospective observational study, women (n = 234) undergoing breast-conserving surgery, mastectomy, or mastectomy with reconstruction completed a brief bedside quantitative sensory testing battery, along with measures of psychosocial characteristics. Postoperative pain severity, impact, and opioid use at 2 weeks were assessed using Brief Pain Inventory and procedure-specific breast cancer pain questionnaires. Moderate-severe average pain (>3/10) was reported by 29% of patients at 2 weeks. Regression analysis of pain outcomes revealed that pain severity was independently predicted by axillary dissection, pre-surgical pain, temporal summation of pain (TSP), (-)positive affect, and behavioral coping style. Pain impact was predicted by age, education, axillary dissection, reconstruction, but also by negative affect and depression scores. Lastly, opioid use was predicted by age, education, axillary dissection, reconstruction, TSP, and reinterpreting coping style. Our findings suggest that, individuals with certain phenotypic characteristics, including high TSP and negative affect, may be at greater risk of significant pain and continued opioid use at 2 weeks after surgery, independent of known surgical risk factors. Perspective: We measured differences in the psychosocial and psychophysical processing of pain amongst patients before breast surgery using simple validated questionnaires and brief quantitative sensory testing. Independent of younger age and procedural extent (axillary surgery and reconstruction), affect and greater temporal summation of pain predicted acute postoperative pain and opioid use.