Publication: Cushing's Syndrome Caused by Ewing's Sarcoma Secreting Corticotropin Releasing Factor-Like Peptide
Issued Date
1992-01-01
Resource Type
ISSN
23742976
00968994
00968994
Other identifier(s)
2-s2.0-0026667744
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Mahidol University
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SCOPUS
Bibliographic Citation
American Journal of Diseases of Children. Vol.146, No.9 (1992), 1103-1105
Suggested Citation
Chawalit Preeyasombat, Vorachai Sirikulchayanonta, Pat Mahachokelertwattana, Arporn Sriphrapradang, Somnate Boonpucknavig Cushing's Syndrome Caused by Ewing's Sarcoma Secreting Corticotropin Releasing Factor-Like Peptide. American Journal of Diseases of Children. Vol.146, No.9 (1992), 1103-1105. doi:10.1001/archpedi.1992.02160210105034 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/22496
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Title
Cushing's Syndrome Caused by Ewing's Sarcoma Secreting Corticotropin Releasing Factor-Like Peptide
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Abstract
Procedures were carried out in a 12-year-old girl to relate Ewing's sarcoma of the left tibia with Cushing's syndrome. Computed tomography revealed a normal pituitary and hypothalamus but bilateral adrenal hyperplasia without focal enlargement, thus readily excluding hypothalamicpituitary-adrenal tumor. Negative results from a high-dose dexamethasone suppression test do not support pituitarydependent Cushing's disease. Ewing's sarcoma was diagnosed on tibial biopsy. The regression of the physical and biochemical findings of Cushing's syndrome subsequent to amputation of the left lower leg strongly suggests ectopic Cushing's syndrome caused by Ewing's sarcoma. Immunohistochemical studies of the resected bone were negative for corticotropin but positive for corticotropin releasing factor-like peptide. We conclude that this is the first reported case of ectopic Cushing's syndrome in a child that is caused by Ewing's sarcoma secreting corticotropin releasing factor-like peptide. © 1992, American Medical Association. All rights reserved.