Publication: Melioidosis: A Major Cause of Community-Acquired Septicemia in Northeastern Thailand
Issued Date
1989-01-01
Resource Type
ISSN
15376613
00221899
00221899
Other identifier(s)
2-s2.0-0024598313
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Mahidol University
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SCOPUS
Bibliographic Citation
Journal of Infectious Diseases. Vol.159, No.5 (1989), 890-899
Suggested Citation
Wipada Chaowagul, Nicholas J. White, David A.B. Dance, Yupaporn Wattanagoon, Pimjai Naigowit, Timothy M.E. Davis, Sornchai Looareesuwan, Nirun Pitakwatchara Melioidosis: A Major Cause of Community-Acquired Septicemia in Northeastern Thailand. Journal of Infectious Diseases. Vol.159, No.5 (1989), 890-899. doi:10.1093/infdis/159.5.890 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/15879
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Title
Melioidosis: A Major Cause of Community-Acquired Septicemia in Northeastern Thailand
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Abstract
In a prospective study of all patients with Pseudomonaspseudomallei infections admitted to a large provincial hospital in northeastern Thailand, 63 cases of septicemic melioidosis and 206 patients with other community-acquired septicemias were documented during a 1-y period. Apart from P. pseudomallei, the spectrum of bacteria isolated from blood cultures and the overall mortality (32%) were similar to those previously reported elsewhere. Death from septicemia was associated with failure to develop a leukocytosis or pyrexia over 38°C, azotemia, hypoglycemia, and jaundice. Septicemic melioidosis presented mainly in the rainy season, occurred predominantly in rice farmers or their families, and was significantly associated with preexisting diabetes mellitus or renal failure (P =.03). Blood-borne pneumonia and visceral abscesses were common and the mortality was high (68%; P < .001). The response to appropriate treatment was slow (median fever clearance time 5.5 d) and the median duration of hospital stay was 4 w. Septicemic meloidosis is a major cause of morbidity and mortality in northeast Thailand. © 1989 by The University of Chicago. All Rights Reserved.