Publication:
Repositioning of the global epicentre of non-optimal cholesterol

Issued Date

2020-06-04

Resource Type

Article

ISSN

14764687
00280836

DOI

10.1038/s41586-020-2338-1

Other identifier(s)

2-s2.0-85085994877

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

Nature. Vol.582, No.7810 (2020), 73-77

Suggested Citation

Cristina Taddei, Bin Zhou, Honor Bixby, Rodrigo M. Carrillo-Larco, Goodarz Danaei, Rod T. Jackson, Farshad Farzadfar, Marisa K. Sophiea, Mariachiara Di Cesare, Maria Laura Caminia Iurilli, Andrea Rodriguez Martinez, Golaleh Asghari, Klodian Dhana, Pablo Gulayin, Sujay Kakarmath, Marilina Santero, Trudy Voortman, Leanne M. Riley, Melanie J. Cowan, Stefan Savin, James E. Bennett, Gretchen A. Stevens, Christopher J. Paciorek, Wichai Aekplakorn, Renata Cifkova, Simona Giampaoli, Andre Pascal Kengne, Young Ho Khang, Kari Kuulasmaa, Avula Laxmaiah, Paula Margozzini, Prashant Mathur, Børge G. Nordestgaard, Dong Zhao, Mette Aadahl, Leandra Abarca-Gómez, Hanan Abdul Rahim, Niveen M. Abu-Rmeileh, Benjamin Acosta-Cazares, Robert J. Adams, Imelda A. Agdeppa, Javad Aghazadeh-Attari, Carlos A. Aguilar-Salinas, Charles Agyemang, Tarunveer S. Ahluwalia, Noor Ani Ahmad, Ali Ahmadi, Naser Ahmadi, Soheir H. Ahmed, Wolfgang Ahrens, Kamel Ajlouni, Monira Alarouj, Fadia AlBuhairan, Shahla AlDhukair, Mohamed M. Ali, Abdullah Alkandari, Ala’a Alkerwi, Eman Aly, Deepak N. Amarapurkar, Philippe Amouyel, Lars Bo Andersen, Sigmund A. Anderssen, Ranjit Mohan Anjana, Alireza Ansari-Moghaddam, Hajer Aounallah-Skhiri, Joana Araújo, Inger Ariansen, Tahir Aris, Raphael E. Arku, Nimmathota Arlappa, Krishna K. Aryal, Thor Aspelund, Maria Cecília F. Assunção, Juha Auvinen, Mária Avdicová, Ana Azevedo, Fereidoun Azizi, Mehrdad Azmin, Nagalla Balakrishna, Mohamed Bamoshmoosh, Maciej Banach, Piotr Bandosz, José R. Banegas, Carlo M. Barbagallo, Alberto Barceló, Amina Barkat, Iqbal Bata, Anwar M. Batieha, Assembekov Batyrbek, Louise A. Baur, Robert Beaglehole, Antonisamy Belavendra, Habiba Ben Romdhane, Mikhail Benet, Marianne Benn, Salim Berkinbayev, Antonio Bernabe-Ortiz, Gailute Bernotiene, Heloisa Bettiol, Santosh K. Bhargava Repositioning of the global epicentre of non-optimal cholesterol. Nature. Vol.582, No.7810 (2020), 73-77. doi:10.1038/s41586-020-2338-1 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/58419

Research Projects

Organizational Units

Authors

Journal Issue

Thesis

Title

Repositioning of the global epicentre of non-optimal cholesterol

Author(s)

Cristina Taddei
 Bin Zhou
 Honor Bixby
 Rodrigo M. Carrillo-Larco
 Goodarz Danaei
 Rod T. Jackson
 Farshad Farzadfar
 Marisa K. Sophiea
 Mariachiara Di Cesare
 Maria Laura Caminia Iurilli
 Andrea Rodriguez Martinez
 Golaleh Asghari
 Klodian Dhana
 Pablo Gulayin
 Sujay Kakarmath
 Marilina Santero
 Trudy Voortman
 Leanne M. Riley
 Melanie J. Cowan
 Stefan Savin
 James E. Bennett
 Gretchen A. Stevens
 Christopher J. Paciorek
 Wichai Aekplakorn
 Renata Cifkova
 Simona Giampaoli
 Andre Pascal Kengne
 Young Ho Khang
 Kari Kuulasmaa
 Avula Laxmaiah
 Paula Margozzini
 Prashant Mathur
 Børge G. Nordestgaard
 Dong Zhao
 Mette Aadahl
 Leandra Abarca-Gómez
 Hanan Abdul Rahim
 Niveen M. Abu-Rmeileh
 Benjamin Acosta-Cazares
 Robert J. Adams
 Imelda A. Agdeppa
 Javad Aghazadeh-Attari
 Carlos A. Aguilar-Salinas
 Charles Agyemang
 Tarunveer S. Ahluwalia
 Noor Ani Ahmad
 Ali Ahmadi
 Naser Ahmadi
 Soheir H. Ahmed
 Wolfgang Ahrens
 Kamel Ajlouni
 Monira Alarouj
 Fadia AlBuhairan
 Shahla AlDhukair
 Mohamed M. Ali
 Abdullah Alkandari
 Ala’a Alkerwi
 Eman Aly
 Deepak N. Amarapurkar
 Philippe Amouyel
 Lars Bo Andersen
 Sigmund A. Anderssen
 Ranjit Mohan Anjana
 Alireza Ansari-Moghaddam
 Hajer Aounallah-Skhiri
 Joana Araújo
 Inger Ariansen
 Tahir Aris
 Raphael E. Arku
 Nimmathota Arlappa
 Krishna K. Aryal
 Thor Aspelund
 Maria Cecília F. Assunção
 Juha Auvinen
 Mária Avdicová
 Ana Azevedo
 Fereidoun Azizi
 Mehrdad Azmin
 Nagalla Balakrishna
 Mohamed Bamoshmoosh
 Maciej Banach
 Piotr Bandosz
 José R. Banegas
 Carlo M. Barbagallo
 Alberto Barceló
 Amina Barkat
 Iqbal Bata
 Anwar M. Batieha
 Assembekov Batyrbek
 Louise A. Baur
 Robert Beaglehole
 Antonisamy Belavendra
 Habiba Ben Romdhane
 Mikhail Benet
 Marianne Benn
 Salim Berkinbayev
 Antonio Bernabe-Ortiz
 Gailute Bernotiene
 Heloisa Bettiol
 Santosh K. Bhargava

Other Contributor(s)

Dasman Diabetes Institute
 University of Science and Technology, Yemen
 Western Norway University of Applied Sciences
 Lietuvos sveikatos mokslų universitetas
 Kazakh National Medical University
 Université de Lille
 Caja Costarricense de Seguro Social
 Beijing Anzhen Hospital, Capital Medical University
 Qatar University
 Birzeit University
 Luxembourg Institute of Health
 Al Farabi Kazakh National University
 Food and Nutrition Research Institute Manila
 Universidad Peruana Cayetano Heredia
 Haskoli Islands
 Jordan University of Science and Technology
 Institute for Clinical Effectiveness and Health Policy, Ciudad Autonoma de Buenos Aires
 University of Tunis El Manar
 National Center for Diabetes, Endocrinology and Genetics Jordan
 Harvard T.H. Chan School of Public Health
 Erasmus MC
 Zahedan University of Medical Sciences
 Pontificia Universidad Católica de Chile
 South African Medical Research Council
 Tehran University of Medical Sciences
 Organisation Mondiale de la Santé
 Universidad Autónoma de Madrid
 The University of Sydney
 Indian Council of Medical Research
 University of California, Berkeley
 Shahid Beheshti University of Medical Sciences, Research Institute for Endocrine Science
 Shahrekord University of Medical Sciences
 Urmia University of Medical Sciences
 Flinders University
 Mohammed V University in Rabat
 Shahid Beheshti University of Medical Sciences
 Rush University Medical Center
 Università degli Studi di Palermo
 National Institute of Nutrition India
 Oulu University Hospital
 Charles University
 Steno Diabetes Center Copenhagen
 Dalhousie University
 Copenhagen University Hospital
 Imperial College London
 Universidade Federal de Pelotas
 University of Massachusetts Amherst
 Middlesex University
 Pan American Health Organization
 Seoul National University
 Oulun Yliopisto
 Kementerian Kesihatan Malaysia
 Mahidol University
 Gdanski Uniwersytet Medyczny
 Norwegian Institute of Public Health
 Bombay Hospital and Medical Research Centre
 Universitetet i Oslo
 Istituto Superiore Di Sanita
 Instituto Nacional de la Nutrición Salvador Zubiran
 Instituto Mexicano del Seguro Social
 University of Bremen
 Universidade de Sao Paulo - USP
 Universidade do Porto
 Frederiksberg Hospital
 Medical University of Lodz
 University of Auckland
 Norges idrettshøgskole
 Harvard Medical School
 Universiteit van Amsterdam
 Christian Medical College, Vellore
 Madras Diabetes Research Foundation
 Abt Associates
 Independent Researcher
 Aldara Hospital and Medical Center
 Cafam University Foundation
 Finnish Institute for Health and Welfare
 National Institute of Public Health
 King Abdullah International Medical Research Center
 Thomayer Hospital
 Regional Authority of Public Health
 Sunder Lal Jain Hospital

Abstract

© 2020, The Author(s), under exclusive licence to Springer Nature Limited. High blood cholesterol is typically considered a feature of wealthy western countries1,2. However, dietary and behavioural determinants of blood cholesterol are changing rapidly throughout the world3 and countries are using lipid-lowering medications at varying rates. These changes can have distinct effects on the levels of high-density lipoprotein (HDL) cholesterol and non-HDL cholesterol, which have different effects on human health4,5. However, the trends of HDL and non-HDL cholesterol levels over time have not been previously reported in a global analysis. Here we pooled 1,127 population-based studies that measured blood lipids in 102.6 million individuals aged 18 years and older to estimate trends from 1980 to 2018 in mean total, non-HDL and HDL cholesterol levels for 200 countries. Globally, there was little change in total or non-HDL cholesterol from 1980 to 2018. This was a net effect of increases in low- and middle-income countries, especially in east and southeast Asia, and decreases in high-income western countries, especially those in northwestern Europe, and in central and eastern Europe. As a result, countries with the highest level of non-HDL cholesterol—which is a marker of cardiovascular risk—changed from those in western Europe such as Belgium, Finland, Greenland, Iceland, Norway, Sweden, Switzerland and Malta in 1980 to those in Asia and the Pacific, such as Tokelau, Malaysia, The Philippines and Thailand. In 2017, high non-HDL cholesterol was responsible for an estimated 3.9 million (95% credible interval 3.7 million–4.2 million) worldwide deaths, half of which occurred in east, southeast and south Asia. The global repositioning of lipid-related risk, with non-optimal cholesterol shifting from a distinct feature of high-income countries in northwestern Europe, north America and Australasia to one that affects countries in east and southeast Asia and Oceania should motivate the use of population-based policies and personal interventions to improve nutrition and enhance access to treatment throughout the world.

Keyword(s)

Multidisciplinary

Availability

URI

https://repository.li.mahidol.ac.th/handle/20.500.14594/58419

Collections

Scopus 2020