Publication:
Cytoadherence characteristics of rosette-forming Plasmodium falciparum

dc.contributor.authorR. Udomsangpetchen_US
dc.contributor.authorH. K. Websteren_US
dc.contributor.authorK. Pattanapanyasaten_US
dc.contributor.authorS. Pitchayangkulen_US
dc.contributor.authorS. Thaithongen_US
dc.contributor.otherMahidol Universityen_US
dc.date.accessioned2018-08-10T08:45:11Z
dc.date.available2018-08-10T08:45:11Z
dc.date.issued1992-01-01en_US
dc.description.abstractSequestration of Plasmodium falciparum-infected erythrocytes to the capillary endothelium can cause obstruction and localized tissue damage. Occlusion of vessels in falciparum malaria infection has been related to two properties of the parasite: adhesion to endothelial cells and rosette formation. Our study on P. falciparum isolates from Thailand producing variable numbers of rosettes suggests the involvement of rosettes in capillary blockage caused by direct adhesion of the rosette-forming infected erythrocytes to various target cells, e.g., live human umbilical vein endothelial cells, monocytes, and platelets. These rosettes did not bind Formalin-fixed target cells, nor did they bind to live or fixed C32 or G361 melanoma cells. Classification of the receptors involved in cytoadherence of endothelial cells and monocytes by specific antibody blocking and flow cytometry indicated that CD36 was involved in the adherence of monocytes but that other receptors besides CD36 may be involved in parasite adherence to endothelial cells. The cytoadherence of infected erythrocytes to monocytes was also associated with CD54 (ICAM-1). Further, differentiation of adherent monocytes resulted in an inversion of CD36 and CD54 levels on the cell surface which correlated with a decrease in surface binding of infected erythrocytes. This observation suggests that the state of cell activation and differentiation may also contribute to sequestration of parasites and to the pathogenesis of malaria.en_US
dc.identifier.citationInfection and Immunity. Vol.60, No.11 (1992), 4483-4490en_US
dc.identifier.issn00199567en_US
dc.identifier.other2-s2.0-0026445984en_US
dc.identifier.urihttps://repository.li.mahidol.ac.th/handle/20.500.14594/22294
dc.rightsMahidol Universityen_US
dc.rights.holderSCOPUSen_US
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0026445984&origin=inwarden_US
dc.subjectImmunology and Microbiologyen_US
dc.titleCytoadherence characteristics of rosette-forming Plasmodium falciparumen_US
dc.typeArticleen_US
dspace.entity.typePublication
mu.datasource.scopushttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0026445984&origin=inwarden_US

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