Publication:
Evaluation of antimycobacterial, antiplasmodial and cytotoxic activities of preussomerins isolated from the lichenicolous fungus Microsphaeropsis sp. BCC 3050

1

Issued Date

2002-02-11

Resource Type

Article

ISSN

00320943

DOI

10.1055/s-2002-20055

Other identifier(s)

2-s2.0-0036152310

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

Planta Medica. Vol.68, No.1 (2002), 45-48

Suggested Citation

Prapairat Seephonkai, Masahiko Isaka, Prasat Kittakoop, Prasit Palittapongarnpim, Sumalee Kamchonwongpaisan, Morakot Tanticharoen, Yodhathai Thebtaranonth Evaluation of antimycobacterial, antiplasmodial and cytotoxic activities of preussomerins isolated from the lichenicolous fungus Microsphaeropsis sp. BCC 3050. Planta Medica. Vol.68, No.1 (2002), 45-48. doi:10.1055/s-2002-20055 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/20081

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Title

Evaluation of antimycobacterial, antiplasmodial and cytotoxic activities of preussomerins isolated from the lichenicolous fungus Microsphaeropsis sp. BCC 3050

Author(s)

Prapairat Seephonkai
 Masahiko Isaka
 Prasat Kittakoop
 Prasit Palittapongarnpim
 Sumalee Kamchonwongpaisan
 Morakot Tanticharoen
 Yodhathai Thebtaranonth

Other Contributor(s)

Mahidol University
 Thailand National Center for Genetic Engineering and Biotechnology

Abstract

A new preussomerin isomer, 3′-O-demethylpreussomerin I, five known preussomerins E-I, and two known deoxypreussomerins, deoxypreussomerin A and bipendensin (palmarumycin C11), were isolated from a lichenicolous fungus Microsphaeropsis sp. BCC 3050. These structures were elucidated by spectroscopic methods, especially 1D- and 2D-NMR. The preussomerins were evaluated for their antimycobacterial and antiplasmodial activities as well as cytotoxicity against KB, BC-1 and vero cell lines.

Keyword(s)

Biochemistry, Genetics and Molecular Biology
 Chemistry
 Medicine
 Pharmacology, Toxicology and Pharmaceutics

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URI

https://repository.li.mahidol.ac.th/handle/123456789/20081

Collections

Scopus 2001-2005