Evaluation of antimycobacterial, antiplasmodial and cytotoxic activities of preussomerins isolated from the lichenicolous fungus Microsphaeropsis sp. BCC 3050
Prapairat Seephonkai, Masahiko Isaka, Prasat Kittakoop, Prasit Palittapongarnpim, Sumalee Kamchonwongpaisan, Morakot Tanticharoen, Yodhathai Thebtaranonth Evaluation of antimycobacterial, antiplasmodial and cytotoxic activities of preussomerins isolated from the lichenicolous fungus Microsphaeropsis sp. BCC 3050. Planta Medica. Vol.68, No.1 (2002), 45-48. doi:10.1055/s-2002-20055 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/20081
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Evaluation of antimycobacterial, antiplasmodial and cytotoxic activities of preussomerins isolated from the lichenicolous fungus Microsphaeropsis sp. BCC 3050
A new preussomerin isomer, 3′-O-demethylpreussomerin I, five known preussomerins E-I, and two known deoxypreussomerins, deoxypreussomerin A and bipendensin (palmarumycin C11), were isolated from a lichenicolous fungus Microsphaeropsis sp. BCC 3050. These structures were elucidated by spectroscopic methods, especially 1D- and 2D-NMR. The preussomerins were evaluated for their antimycobacterial and antiplasmodial activities as well as cytotoxicity against KB, BC-1 and vero cell lines.
