Publication:
Dynamic changes in white blood cell counts in uncomplicated Plasmodium falciparum and P. vivax malaria

dc.contributor.authorNoppadon Tangpukdeeen_US
dc.contributor.authorHaur Sen Yewen_US
dc.contributor.authorSrivicha Krudsooden_US
dc.contributor.authorNataya Punyapraditen_US
dc.contributor.authorWaraporn Somwongen_US
dc.contributor.authorSornchai Looareesuwanen_US
dc.contributor.authorShigeyuki Kanoen_US
dc.contributor.authorPolrat Wilairatanaen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherNational Center for Global Health and Medicineen_US
dc.date.accessioned2018-07-12T02:28:17Z
dc.date.available2018-07-12T02:28:17Z
dc.date.issued2008-12-01en_US
dc.description.abstractTotal and differential white blood cell (WBC) counts are basic and essential indicators in any type of illness resulting from infection. In malaria, WBC counts are generally characterized as low to normal during treatment. WBC-counts data, before and during treatment with artemisinin derivatives, was gathered for patients with either Plasmodium falciparum or Plasmodium vivax infection (at 28-day follow-up), to investigate dynamic changes in WBC count. We analyzed and compared the WBC counts of 1310 inpatients presenting with uncomplicated P. falciparum and P. vivax malaria at the Hospital for Tropical Diseases, in Bangkok, Thailand. Before-treatment, a statistically significant negative correlation was found between initial WBC count and highest temperature on admission. Before and during treatment, WBC counts were significantly lower in P. falciparum than P. vivax infection on days 0 and 7, but the numerical difference was small. We also found clinically significantly low WBC counts during the acute stages of both types of malaria, which subsequently normalized by day 28 follow-up. This finding has important clinical implications for the conventional method of estimating parasitemia using an assumed WBC count of 8000 cells/μL. The most significant finding in our analysis is that WBC counts in acute P. falciparum and P. vivax malaria are significantly lower than previously assumed for estimating malaria-parasite density. However, these abnormalities returned to normal within several weeks after artemisinin-derivative-based treatment. © 2008 Elsevier Ireland Ltd. All rights reserved.en_US
dc.identifier.citationParasitology International. Vol.57, No.4 (2008), 490-494en_US
dc.identifier.doi10.1016/j.parint.2008.06.005en_US
dc.identifier.issn13835769en_US
dc.identifier.other2-s2.0-53049091076en_US
dc.identifier.urihttps://repository.li.mahidol.ac.th/handle/123456789/19263
dc.rightsMahidol Universityen_US
dc.rights.holderSCOPUSen_US
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=53049091076&origin=inwarden_US
dc.subjectImmunology and Microbiologyen_US
dc.subjectMedicineen_US
dc.titleDynamic changes in white blood cell counts in uncomplicated Plasmodium falciparum and P. vivax malariaen_US
dc.typeArticleen_US
dspace.entity.typePublication
mu.datasource.scopushttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=53049091076&origin=inwarden_US

Files

Collections