Publication: 12-Amino-andrographolide analogues: Synthesis and cytotoxic activity
1
Issued Date
2013-12-01
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ISSN
19763786
02536269
02536269
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2-s2.0-84890798430
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Mahidol University
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SCOPUS
Bibliographic Citation
Archives of Pharmacal Research. Vol.36, No.12 (2013), 1454-1464
Suggested Citation
Sakkasem Kasemsuk, Uthaiwan Sirion, Kanoknetr Suksen, Pawinee Piyachaturawat, Apichart Suksamrarn, Rungnapha Saeeng 12-Amino-andrographolide analogues: Synthesis and cytotoxic activity. Archives of Pharmacal Research. Vol.36, No.12 (2013), 1454-1464. doi:10.1007/s12272-013-0152-0 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/31153
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Title
12-Amino-andrographolide analogues: Synthesis and cytotoxic activity
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Abstract
Andrographolide, a diterpenoid lactone of the plant Andrographis paniculata, has been shown to be cytotoxic against various cancer cells in vitro. In the present study, a series of β-amino-γ-butyrolactone analogues has been synthesized from naturally occurring andrographolide via one pot tandem aza-conjugate addition-elimination reaction. By using economic procedure without any base or catalyst at room temperature, the products obtained were in fair to excellent yields with high stereoselectivity. The cytotoxicity of all new amino analogues were evaluated against six cancer cell lines and revealed their potential for being developed as promising anti-cancer agents. © 2013 The Pharmaceutical Society of Korea.