Publication: Possible protective effects of the Glu27 allele of ß2- Adrenergic receptor polymorphism in Thai asthmatic patients
Issued Date
2010-06-01
Resource Type
ISSN
0125877X
Other identifier(s)
2-s2.0-78649497839
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Asian Pacific Journal of Allergy and Immunology. Vol.28, No.2-3 (2010), 107-114
Suggested Citation
Ticha Limsuwan, Ammarin Thakkinstian, Oravan Verasertniyom, Monchand Vanichapuntu, John Attia, Suchela Janwityanujit, Kanokrat Nantiruj Possible protective effects of the Glu27 allele of ß2- Adrenergic receptor polymorphism in Thai asthmatic patients. Asian Pacific Journal of Allergy and Immunology. Vol.28, No.2-3 (2010), 107-114. Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/29230
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
Possible protective effects of the Glu27 allele of ß2- Adrenergic receptor polymorphism in Thai asthmatic patients
Other Contributor(s)
Abstract
The genetic polymorphisms at the 16th (Arg→ Gly) and 27th (Gln→Glu) amino acid positions of the ß2-adrenergic receptor (ADRB2) may be linked to various asthma-related phenotypes. These include the adverse effects on lung function known to occur following the regular use of albuterol. The study aimed to determine the association between these two ADRB2 SNPs, their haplotypes and the phenotypes in Thai asthmatic patients. One-hundred and thirty asthmatic patients were genotyped at the Arg16Gly and Gln27Glu polymorphisms. Demographic data, disease severities, pulmonary function tests and medication usages were recorded for each patient. The frequencies of the Arg16 and Gln27 alleles were found to be 56.9% and 91.2%, respectively, while the linkage disequilibrium coefficient between the two SNPs was 0.36. Three haplotypes were estimated, i.e. Arg-Gln, Gly-Gln and Gly-Glu with frequencies of 148 (56.9%), 89 (34.2%) and 23 (8.9%), respectively. The mean percentages for predicted FEV1 (%FEV1) for these corresponding haplotypes were 73.5 (SD = 16.3), 72.4 (SD = 17.4) and 80.7 (SD = 13.1), respectively (p = 0.258). Additionally, the number of hospitalizations, emergency visits and inhaled corticosteroid/longacting ß2-agonist (ICS/ LABA) usages were lower in Gln/Glu subjects than for Gln/Gln genotyped patients, with values of 0% versus 11.9% (p = 0.122) for hospitalizations;4.5% versus 18.8% (p = 0.121) for emergency visits; and 50% versus 76.6%, (p = 0.042) for ICS/LABA usages. The presence of the Glu27 allele in Thai asthmatic patients is associated with a decreased asthma severity, higher %FEV1 values, less frequent hospitalizations and emergency visits, and decreased ICS/LABA usage.