Publication: Biosafety and biosecurity requirements for Orientia spp. diagnosis and research: Recommendations for risk-based biocontainment, work practices and the case for reclassification to risk group 2
Issued Date
2019-12-10
Resource Type
ISSN
14712334
Other identifier(s)
2-s2.0-85076339022
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
BMC Infectious Diseases. Vol.19, No.1 (2019)
Suggested Citation
Stuart D. Blacksell, Matthew T. Robinson, Paul N. Newton, Soiratchaneekorn Ruanchaimun, Jeanne Salje, Tri Wangrangsimakul, Matthew D. Wegner, Mohammad Yazid Abdad, Allan M. Bennett, Allen L. Richards, John Stenos, Nicholas P.J. Day Biosafety and biosecurity requirements for Orientia spp. diagnosis and research: Recommendations for risk-based biocontainment, work practices and the case for reclassification to risk group 2. BMC Infectious Diseases. Vol.19, No.1 (2019). doi:10.1186/s12879-019-4653-4 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/51245
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
Biosafety and biosecurity requirements for Orientia spp. diagnosis and research: Recommendations for risk-based biocontainment, work practices and the case for reclassification to risk group 2
Abstract
© 2019 The Author(s). Scrub typhus is an important arthropod-borne disease causing significant acute febrile illness by infection with Orientia spp. Using a risk-based approach, this review examines current practice, the evidence base and regulatory requirements regarding matters of biosafety and biosecurity, and presents the case for reclassification from Risk Group 3 to Risk Group 2 along with recommendations for safe working practices of risk-based activities during the manipulation of Orientia spp. in the laboratory. We recommend to reclassify Orientia spp. to Risk Group 2 based on the classification for RG2 pathogens as being moderate individual risk, low community risk. We recommend that low risk activities, can be performed within a biological safety cabinet located in a Biosafety Level (BSL) 2 core laboratory using standard personal protective equipment. But when the risk assessment indicates, such as high concentration and volume, or aerosol generation, then a higher biocontainment level is warranted. For, the majority of animal activities involving Orientia spp., Animal BSL 2 (ABSL2) is recommended however where high risk activities are performed including necropsies, Animal BSL (ABSL3) is recommended.