Publication: Acquisition and Longevity of Antibodies to Plasmodium vivax Preerythrocytic Antigens in Western Thailand
Issued Date
2016-02-01
Resource Type
ISSN
1556679X
15566811
15566811
Other identifier(s)
2-s2.0-84958629564
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Mahidol University
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SCOPUS
Bibliographic Citation
Clinical and Vaccine Immunology. Vol.23, No.2 (2016), 117-124
Suggested Citation
Rhea J. Longley, Arturo Reyes-Sandoval, Eduardo Montoya-Díaz, Susanna Dunachie, Chalermpon Kumpitak, Wang Nguitragool, Ivo Mueller, Jetsumon Sattabongkot Acquisition and Longevity of Antibodies to Plasmodium vivax Preerythrocytic Antigens in Western Thailand. Clinical and Vaccine Immunology. Vol.23, No.2 (2016), 117-124. doi:10.1128/CVI.00501-15 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/43163
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Title
Acquisition and Longevity of Antibodies to Plasmodium vivax Preerythrocytic Antigens in Western Thailand
Abstract
Copyright © 2016 American Society for Microbiology. All Rights Reserved. Plasmodium vivax is now the dominant Plasmodium species causing malaria in Thailand, yet little is known about naturally acquired immune responses to this parasite in this low-transmission region. The preerythrocytic stage of the P. vivax life cycle is considered an excellent target for a malaria vaccine, and in this study, we assessed the stability of the seropositivity and the magnitude of IgG responses to three different preerythrocytic P. vivax proteins in two groups of adults from a region of western Thailand where malaria is endemic. These individuals were enrolled in a yearlong cohort study, which comprised one group that remained P. vivax free (by quantitative PCR [qPCR] detection, no31) and another that experienced two or more blood-stage P. vivax infections during the year of follow up (no31). Despite overall low levels of seropositivity, IgG positivity and magnitude were long-lived over the 1-year period in the absence of qPCR-detectable blood-stage P. vivax infections. In contrast, in the adults with two or more P. vivax infections during the year, IgG positivity was maintained, but the magnitude of the response to P. vivax circumsporozoite protein 210 (CSP210) decreased over time. These findings demonstrate that long-term humoral immunity can develop in low-transmission regions.