Publication: A method to differentiate between anti-C1q antibodies and C1q-binding immune complexes using collagenase-digested solid phase C1q
| dc.contributor.author | Johannes E. Menzel | en_US |
| dc.contributor.author | Othmar Scherak | en_US |
| dc.contributor.author | Gernot Kolarz | en_US |
| dc.contributor.author | Fritz Gamerith | en_US |
| dc.contributor.author | Uriwan Youngchaiyud | en_US |
| dc.contributor.other | Medizinische Universitat Wien, Instituts fur Immunologie | en_US |
| dc.contributor.other | Ludwig Boltzmann Institute | en_US |
| dc.contributor.other | Mahidol University | en_US |
| dc.date.accessioned | 2018-08-10T08:30:41Z | |
| dc.date.available | 2018-08-10T08:30:41Z | |
| dc.date.issued | 1991-04-25 | en_US |
| dc.description.abstract | A method for the detection of circulating immune complexes in the presence of autoantibodies to C1q is described. Solid phase C1q-digestion with bacterial collagenase results in the elimination of the collagen-like region of C1q. Binding of model immune complexes to this modified solid phase C1q is practically unaltered, while reactivity of anti-C1q antibodies is abolished by this procedure. In conjunction with an ELISA using the collagen-like region of C1q as antigen this modified C1q solid phase assay may be used to determine immune complexes and anti-C1q antibodies in the sera of patients with autoimmune rheumatic diseases. © 1991. | en_US |
| dc.identifier.citation | Journal of Immunological Methods. Vol.138, No.2 (1991), 165-171 | en_US |
| dc.identifier.doi | 10.1016/0022-1759(91)90164-B | en_US |
| dc.identifier.issn | 00221759 | en_US |
| dc.identifier.other | 2-s2.0-0025780219 | en_US |
| dc.identifier.uri | https://repository.li.mahidol.ac.th/handle/20.500.14594/21989 | |
| dc.rights | Mahidol University | en_US |
| dc.rights.holder | SCOPUS | en_US |
| dc.source.uri | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0025780219&origin=inward | en_US |
| dc.subject | Biochemistry, Genetics and Molecular Biology | en_US |
| dc.subject | Immunology and Microbiology | en_US |
| dc.title | A method to differentiate between anti-C1q antibodies and C1q-binding immune complexes using collagenase-digested solid phase C1q | en_US |
| dc.type | Article | en_US |
| dspace.entity.type | Publication | |
| mu.datasource.scopus | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0025780219&origin=inward | en_US |