Publication: The significance of HER-2/neu/c-erbB-2 gene amplification in benign and malignant breast disease
Issued Date
1997-09-01
Resource Type
ISSN
01251562
Other identifier(s)
2-s2.0-0031219588
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Mahidol University
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SCOPUS
Bibliographic Citation
Southeast Asian Journal of Tropical Medicine and Public Health. Vol.28, No.3 (1997), 631-640
Suggested Citation
Kasama Supanaranond, Saowakon Sukarayodhin, Manu Tanyakaset, Kruavon Balachandra, Duangrat Jullaksorn, Mati Rienkijkarn, Narin Hoisanka, Surang Tantivanich The significance of HER-2/neu/c-erbB-2 gene amplification in benign and malignant breast disease. Southeast Asian Journal of Tropical Medicine and Public Health. Vol.28, No.3 (1997), 631-640. Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/18101
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Title
The significance of HER-2/neu/c-erbB-2 gene amplification in benign and malignant breast disease
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Abstract
This study was carried out to investigate the amplification of HER-2/neu oncogene in 66 patients with primary breast cancer and 90 samples from benign breast disease (BBD). The amplification of HER-2/neu oncogene in the DNA of paraffin-embedded specimens was determined by differential PCR. Nineteen out of 66 (28.8%) breast cancer patients showed amplification of the gene. No gene amplification was found in benign breast disease. There was no significant correlation of HER-2/neu amplification with, age, menopausal status, the number of positive nodes, tumor size, estrogen receptor, however, amplification of HER-2/neu gene was strongly correlated with nodal status (p = 0.0049). In node positive patients, the incidence of HER-2/neu amplification was high (43%). These findings indicate that the amplification of HER-2/neu gene may be of pathogenetic significance in breast cancer and may have a poor prognosis in node positive breast cancer patients while no gene amplification in benign breast disease suggests that HER-2/ neu amplification is a late molecular alteration event in the pathogenesis of breast cancer.