Publication: Immunome and immune complex-forming components of Brugia malayi identified by microfilaremic human sera
Issued Date
2019-05-01
Resource Type
ISSN
10902449
00144894
00144894
Other identifier(s)
2-s2.0-85064759898
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Mahidol University
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SCOPUS
Bibliographic Citation
Experimental Parasitology. Vol.200, (2019), 92-98
Suggested Citation
Onrapak Reamtong, Kitiya Rujimongkon, Nitat Sookrung, Atiporn Saeung, Tipparat Thiangtrongjit, Yuwaporn Sakolvaree, Suwich Thammapalo, Sumat Loymek, Wanpen Chaicumpa Immunome and immune complex-forming components of Brugia malayi identified by microfilaremic human sera. Experimental Parasitology. Vol.200, (2019), 92-98. doi:10.1016/j.exppara.2019.04.005 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/51071
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Title
Immunome and immune complex-forming components of Brugia malayi identified by microfilaremic human sera
Abstract
© 2019 Adult Brugia malayi proteins with high potential as epidemiological markers, diagnostic and therapeutic targets, and/or vaccine candidates were revealed by using microfilaremic human sera and an immunoproteomic approach. They were HSP70, cytoplasmic intermediate filament protein, independent phosphoglycerate mutase, and enolase. Brugia malayi microfilaria-specific proteins that formed circulating immune complexes (ICs)were investigated. The IC-forming proteins were orthologues of hypothetical protein Bm1_12480, Pao retrotransposon peptidase family protein, uncoordinated protein 44, NAD-binding domain containing protein of the UDP-glucose/GDP-mannose dehydrogenase family which contained ankyrin repeat region, ZU5 domain with C-terminal death domain, C2 domain containing protein, and FLJ90013 protein of the eukaryotic membrane protein family. Antibodies to these proteins were not free in the microfilaremic sera, raising the possible role of the IC-forming proteins in an immune evasion mechanism of the circulating microfilariae to avoid antibody-mediated-host immunity. Moreover, detection of these ICs should be able to replace the inconvenient night blood sampling for microfilaria in an evaluation of efficacy of anti-microfilarial agents.