Publication: Intestinal mucosal defense system, Part 2. Probiotics and prebiotics
Issued Date
2013-04-02
Resource Type
ISSN
10976833
00223476
00223476
Other identifier(s)
2-s2.0-84875460472
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Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Journal of Pediatrics. Vol.162, No.3 SUPPL. (2013)
Suggested Citation
Teresa Murguía-Peniche, Walter A. Mihatsch, Jaime Zegarra, Sarayut Supapannachart, Zong Yi Ding, Josef Neu Intestinal mucosal defense system, Part 2. Probiotics and prebiotics. Journal of Pediatrics. Vol.162, No.3 SUPPL. (2013). doi:10.1016/j.jpeds.2012.11.055 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/32402
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Title
Intestinal mucosal defense system, Part 2. Probiotics and prebiotics
Abstract
The interplay between microorganisms and the intestine of newborn infants is associated with diverse functional and clinical outcomes that result from the specific interactions among microbial communities, their products, and the unique characteristics of the gastrointestinal tract. Multiple mechanisms of action for infant formula ingredients with probiotic activity appear to exist. These mechanisms are thought to protect the host not only from intestinal diseases but also from systemic infection. However, questions about the safety of probiotics for preterm infants remain unanswered, particularly with regard to sepsis, immunomodulatory effects, and microbial resistance. Few well-designed studies have been conducted to evaluate the effects of probiotic, prebiotic, and synbiotic ingredients on relevant clinical outcomes in preterm infants. Although existing data are encouraging, there is insufficient evidence to recommend the routine use of these ingredients in all preterm infants.