Publication: EFFECTIVENESS OF SMS 201-995, A SYNTHETIC, LONG-ACTING SOMATOSTATIN ANALOGUE, IN TREATMENT OF QUININE-INDUCED HYPERINSULINAEMIA
| dc.contributor.author | R. E. Phillips | en_US |
| dc.contributor.author | S. Looareesuwan | en_US |
| dc.contributor.author | S. R. Bloom | en_US |
| dc.contributor.author | D. A. Warrell | en_US |
| dc.contributor.author | R. C. Turner | en_US |
| dc.contributor.author | D. Quantrill | en_US |
| dc.contributor.author | A. R. Moore | en_US |
| dc.contributor.other | Mahidol University | en_US |
| dc.contributor.other | John Radcliffe Hospital | en_US |
| dc.contributor.other | Hammersmith Hospital | en_US |
| dc.date.accessioned | 2018-02-27T04:28:59Z | |
| dc.date.available | 2018-02-27T04:28:59Z | |
| dc.date.issued | 1986-03-29 | en_US |
| dc.description.abstract | SMS 201-995, a new long-acting, synthetic somatostatin analogue, dose 50 μg/h, given as a continuous intravenous infusion, completely abolished quinine-induced insulin release in 9 healthy Thai volunteers. Hyperinsulinaemia, which caused sustained hypoglycaemia in a 32-year-old post-partum Thai patient who was receiving intravenous quinine for falciparum malaria, was suppressed within 30 min of starting SMS 201-995, and the patient became fully conscious. This octapeptide antagonises the stimulatory effect of quinine on the pancreatic beta cell and is a specific therapy for life-threatening hyperinsulinaemic hypoglycaemia complicating falciparum malaria. © 1986. | en_US |
| dc.identifier.citation | The Lancet. Vol.327, No.8483 (1986), 713-716 | en_US |
| dc.identifier.doi | 10.1016/S0140-6736(86)91103-7 | en_US |
| dc.identifier.issn | 01406736 | en_US |
| dc.identifier.other | 2-s2.0-0022593162 | en_US |
| dc.identifier.uri | https://repository.li.mahidol.ac.th/handle/20.500.14594/9809 | |
| dc.rights | Mahidol University | en_US |
| dc.rights.holder | SCOPUS | en_US |
| dc.source.uri | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0022593162&origin=inward | en_US |
| dc.subject | Medicine | en_US |
| dc.title | EFFECTIVENESS OF SMS 201-995, A SYNTHETIC, LONG-ACTING SOMATOSTATIN ANALOGUE, IN TREATMENT OF QUININE-INDUCED HYPERINSULINAEMIA | en_US |
| dc.type | Article | en_US |
| dspace.entity.type | Publication | |
| mu.datasource.scopus | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0022593162&origin=inward | en_US |