Publication: Polygenic Risk Scores for Atherosclerotic Cardiovascular Disease in the Asia-Pacific Region
Issued Date
2021-12-01
Resource Type
ISSN
27723747
Other identifier(s)
2-s2.0-85132177662
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Mahidol University
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SCOPUS
Bibliographic Citation
JACC: Asia. Vol.1, No.3 (2021), 294-302
Suggested Citation
Hayato Tada, Khung Keong Yeo, Jian Jun Li, Kathryn Tan, Junya Ako, Rungroj Krittayaphong, Ru San Tan, Philip E. Aylward, Carolyn S.P. Lam, Sang Hong Baek, Jamshed Dalal, Alan Fong, Yi Heng Li, Richard C. O'Brien, Si Ya Natalie Koh, Daniel J. Scherer, Vernon Kang, Adam J. Nelson, Julie Butters, Stephen J. Nicholls Polygenic Risk Scores for Atherosclerotic Cardiovascular Disease in the Asia-Pacific Region. JACC: Asia. Vol.1, No.3 (2021), 294-302. doi:10.1016/j.jacasi.2021.08.008 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/77412
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Title
Polygenic Risk Scores for Atherosclerotic Cardiovascular Disease in the Asia-Pacific Region
Author(s)
Other Contributor(s)
Siriraj Hospital
Kanazawa University Graduate School of Medical Sciences
South Australian Health and Medical Research Institute
National Cheng Kung University Hospital
Fuwai Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College
University of Melbourne
Flinders University
Monash University
Sarawak General Hospital
The University of Hong Kong
Kitasato University
National Heart Centre, Singapore
The Catholic University of Korea, College of Medicine
Singapore Heart Foundation
Kokilaben Hospital
Kanazawa University Graduate School of Medical Sciences
South Australian Health and Medical Research Institute
National Cheng Kung University Hospital
Fuwai Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College
University of Melbourne
Flinders University
Monash University
Sarawak General Hospital
The University of Hong Kong
Kitasato University
National Heart Centre, Singapore
The Catholic University of Korea, College of Medicine
Singapore Heart Foundation
Kokilaben Hospital
Abstract
Approximately one-half of the phenotypic susceptibility to atherosclerotic cardiovascular disease (ASCVD) has a genetic basis. Although individual allelic variants generally impart a small effect on risk for ASCVD, an emerging body of data has shown that the aggregation and weighting of many of these genetic variations into “scores” can further discriminate an individual's risk beyond traditional risk factors alone. Consistent with the theory of population genetics, such polygenic risk scores (PRS) appear to be ethnicity specific because their elements comprise single-nucleotide variants that are always ethnicity specific. The currently available PRS are derived predominantly from European ancestry and thus predictably perform less well among non-European participants, a fact that has implications for their use in the Asia-Pacific region. This paper describes the current state of knowledge of PRS, the available data that support their use in this region, and highlights the needs moving forward to safely and effectively implement them in clinical care in the Asia-Pacific region.