Publication: Melatonin attenuates the amphetamine-induced decrease in vesicular monoamine transporter-2 expression in postnatal rat striatum
Issued Date
2011-01-20
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ISSN
03043940
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2-s2.0-78650680937
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Mahidol University
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SCOPUS
Bibliographic Citation
Neuroscience Letters. Vol.488, No.2 (2011), 154-157
Suggested Citation
Sujira Mukda, Oranich Vimolratana, Piyarat Govitrapong Melatonin attenuates the amphetamine-induced decrease in vesicular monoamine transporter-2 expression in postnatal rat striatum. Neuroscience Letters. Vol.488, No.2 (2011), 154-157. doi:10.1016/j.neulet.2010.11.019 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/12792
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Title
Melatonin attenuates the amphetamine-induced decrease in vesicular monoamine transporter-2 expression in postnatal rat striatum
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Abstract
The vesicular monoamine transporter-2 (VMAT-2) is responsible for packaging intraneuronal dopamine into synaptic vesicles in preparation for synaptic release and is a critical regulator of cytoplasmic dopamine levels and dopaminergic function. It has long been recognized that VMAT-2 is also a critical mediator of amphetamine-induced dopamine release. Amphetamine-induced lesions during development have the potential to produce numerous permanent abnormalities in neural circuitry and function. Therefore, in the present study, we investigated the effects of amphetamine on the levels of VMAT-2, α-synuclein and phosphorylated tyrosine hydroxylase in the striatum of neonatal rats. We found that chronic amphetamine administration in postnatal rats produces dopaminergic deficits in the striatum, including decreases in the levels of VMAT-2 and phosphorylated tyrosine hydroxylase. In addition, an increase in α-synuclein expression was observed in the striatum of postnatal rats following chronic amphetamine treatment. Furthermore, we identified a role of (10 mg/kg) melatonin, a methoxyindole released from the pineal gland, in attenuating the detrimental effects of amphetamine on dopaminergic neurons. © 2010 Elsevier Ireland Ltd.